Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies

Mutations in the Parkinson's disease (PD)-associated protein leucine-rich repeat kinase 2 (LRRK2) commonly lead to a reduction of GTPase activity and increase in kinase activity. Therefore, strategies for drug development have mainly been focusing on the design of LRRK2 kinase inhibitors. We re...

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Detalles Bibliográficos
Autores principales: Leemans, Margaux, Galicia, Christian, Deyaert, Egon, Daems, Elise, Krause, Linda, Paesmans, Jone, Pardon, Els, Steyaert, Jan, Kortholt, Arjan, Sobott, Frank, Klostermeier, Dagmar, Versées, Wim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135905/
https://www.ncbi.nlm.nih.gov/pubmed/32167135
http://dx.doi.org/10.1042/BCJ20190843

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