HSF1 phase transition mediates stress adaptation and cell fate decisions

Under proteotoxic stress, some cells survive whereas others die. Mechanisms governing this heterogeneity in cell fate are unknown. We report that condensation and phase transition of heat-shock factor 1 (HSF1), a transcriptional regulator of chaperones(1,2), is integral to cell fate decisions underl...

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Detalles Bibliográficos
Autores principales: Gaglia, Giorgio, Rashid, Rumana, Yapp, Clarence, Joshi, Gaurav N., Li, Carmen G., Lindquist, Susan L., Sarosiek, Kris A., Whitesell, Luke, Sorger, Peter K., Santagata, Sandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135912/
https://www.ncbi.nlm.nih.gov/pubmed/32015439
http://dx.doi.org/10.1038/s41556-019-0458-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135912/
https://www.ncbi.nlm.nih.gov/pubmed/32015439
http://dx.doi.org/10.1038/s41556-019-0458-3

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