Cargando…

An engineered enzyme that targets circulating lactate to alleviate intracellular NADH/NAD(+) imbalance

An elevated intracellular NADH/NAD(+) ratio, or “reductive stress”, has been associated with multiple diseases, including disorders of the mitochondrial electron transport chain (ETC). As the intracellular NADH/NAD(+) ratio can be in near equilibrium with the circulating lactate/pyruvate ratio, we h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Patgiri, Anupam, Skinner, Owen S., Miyazaki, Yusuke, Schleifer, Grigorij, Marutani, Eizo, Shah, Hardik, Sharma, Rohit, Goodman, Russell P., To, Tsz-Leung, Bao, Xiaoyan Robert, Ichinose, Fumito, Zapol, Warren M., Mootha, Vamsi K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135927/ https://www.ncbi.nlm.nih.gov/pubmed/31932725 http://dx.doi.org/10.1038/s41587-019-0377-7

Ejemplares similares

Impaired hypoxic pulmonary vasoconstriction in a mouse model of Leigh syndrome
por: Schleifer, Grigorij, et al.
Publicado: (2019)

Hepatic NADH reductive stress underlies common variation in metabolic traits
por: Goodman, Russell P., et al.
Publicado: (2020)

Continuous, but not intermittent, regimens of hypoxia prevent and reverse ataxia in a murine model of Friedreich’s ataxia
por: Ast, Tslil, et al.
Publicado: (2023)

NADH/NAD(+) Redox Imbalance and Diabetic Kidney Disease
por: Yan, Liang-Jun
Publicado: (2021)

Emerging pharmacological tools to control hydrogen sulfide signaling in critical illness
por: Marutani, Eizo, et al.
Publicado: (2020)

Sources and implications of NADH/NAD(+) redox imbalance in diabetes and its complications
por: Wu, Jinzi, et al.
Publicado: (2016)

Tolerance to NADH/NAD(+) imbalance anticipates aging and anti-aging interventions
por: Alonso-Lavin, Alvar J., et al.
Publicado: (2021)

Assessment of NADH/NAD(+) Redox Imbalance in Psoriatic Lesions Using the FMSF Technique: Therapeutic Aspects
por: Gebicki, Jerzy, et al.
Publicado: (2023)

Intranasal administration of polysulfide prevents neurodegeneration in spinal cord and rescues mice from delayed paraplegia after spinal cord ischemia
por: Kanemaru, Eiki, et al.
Publicado: (2023)

A scalable metabolite supplementation strategy against antibiotic resistant pathogen Chromobacterium violaceum induced by NAD(+)/NADH(+) imbalance
por: Banerjee, Deepanwita, et al.
Publicado: (2017)

Mitochondrial NAD(+)/NADH Redox State and Diabetic Cardiomyopathy
por: Berthiaume, Jessica M., et al.
Publicado: (2019)

Methotrexate use and NAD(+)/NADH metabolism in psoriatic keratinocytes
por: Liszewska, Agata, et al.
Publicado: (2020)

Trapping Hydrogen Sulfide (H(2)S) with Diselenides: The Application in the Design of Fluorescent Probes
por: Peng, Bo, et al.
Publicado: (2015)

Mitochondrial dysfunction remodels one-carbon metabolism in human cells
por: Bao, Xiaoyan Robert, et al.
Publicado: (2016)

Biochemical Issues in Estimation of Cytosolic Free NAD/NADH Ratio
por: Sun, Feifei, et al.
Publicado: (2012)

Rapamycin maintains NAD(+)/NADH redox homeostasis in muscle cells
por: Zhang, Zhigang, et al.
Publicado: (2020)

Arginase impairs hypoxic pulmonary vasoconstriction in murine endotoxemia
por: Petersen, Bodil, et al.
Publicado: (2019)

The extracellular lactate-to-pyruvate ratio modulates the sensitivity to oxidative stress-induced apoptosis via the cytosolic NADH/NAD(+) redox state
por: Go, Simei, et al.
Publicado: (2020)

The mechanism of RNA 5′ capping with NAD(+), NADH, and desphospho-CoA
por: Bird, Jeremy G., et al.
Publicado: (2016)

Cofactor engineering to regulate NAD(+)/NADH ratio with its application to phytosterols biotransformation
por: Su, Liqiu, et al.
Publicado: (2017)

In Vivo NADH/NAD(+) Biosensing Reveals the Dynamics of Cytosolic Redox Metabolism in Plants
por: Steinbeck, Janina, et al.
Publicado: (2020)

Genetically encoded biosensors for evaluating NAD(+)/NADH ratio in cytosolic and mitochondrial compartments
por: Hu, Qingxun, et al.
Publicado: (2021)

Sex-related differences in human plasma NAD(+)/NADH levels depend on age
por: Schwarzmann, Luisa, et al.
Publicado: (2021)

Influence of electrode potential, pH and NAD(+) concentration on the electrochemical NADH regeneration
por: Aamer, Emad, et al.
Publicado: (2022)

Investigation of NADH Binding, Hydride Transfer, and NAD(+) Dissociation during NADH Oxidation by Mitochondrial Complex I Using Modified Nicotinamide Nucleotides
por: Birrell, James A., et al.
Publicado: (2013)

Imaging the NADH:NAD(+) Homeostasis for Understanding the Metabolic Response of Mycobacterium to Physiologically Relevant Stresses
por: Bhat, Shabir A., et al.
Publicado: (2016)

Insights into the inhibitory mechanisms of NADH on the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase
por: Liu, Yabing, et al.
Publicado: (2018)

Toxicity of Melaleuca alternifolia essential oil to the mitochondrion and NAD(+)/NADH dehydrogenase in Tribolium confusum
por: Liao, Min, et al.
Publicado: (2018)

Tracking the Courier: In Planta Imaging of NADH/NAD(+) Ratios with a Genetically Encoded Biosensor
por: Hõrak, Hanna
Publicado: (2020)

In planta study of photosynthesis and photorespiration using NADPH and NADH/NAD(+) fluorescent protein sensors
por: Lim, Shey-Li, et al.
Publicado: (2020)

Neuroprotection in Glaucoma: NAD(+)/NADH Redox State as a Potential Biomarker and Therapeutic Target
por: Petriti, Bledi, et al.
Publicado: (2021)

Sulfide:quinone oxidoreductase ameliorates neurodegeneration in a murine model of Parkinson's disease
por: Nagashima, Fumiaki, et al.
Publicado: (2022)

Synthesis of [4S‐(2)H]NADH, [4R‐(2)H]NADH, [4‐(2)H(2)]NADH and [4‐(2)H]NAD(+) cofactors through heterogeneous biocatalysis in heavy water
por: Rowbotham, Jack S., et al.
Publicado: (2021)

Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD(+) redox
por: Yang, Liang, et al.
Publicado: (2020)

Protocols for analyzing metabolic derangements caused by increased NADH/NAD(+) ratio in cell lines and in mice
por: Liu, Shanshan, et al.
Publicado: (2022)

Dysregulated NAD(H) homeostasis associated with ciprofloxacin tolerance in Escherichia coli investigated on a single-cell level with the Peredox [NADH:NAD+] biosensor
por: Urbaniec, Joanna, et al.
Publicado: (2023)

Oral Administration of Glutathione Trisulfide Increases Reactive Sulfur Levels in Dorsal Root Ganglion and Ameliorates Paclitaxel-Induced Peripheral Neuropathy in Mice
por: Ezaka, Mariko, et al.
Publicado: (2022)

Inhibition of mitochondrial complex I leading to NAD(+)/NADH imbalance in type 2 diabetic patients who developed late stent thrombosis: Evidence from an integrative analysis of platelet bioenergetics and metabolomics
por: Gao, Mi-jie, et al.
Publicado: (2022)

Cofactor Specificity Engineering of Streptococcus mutans NADH Oxidase 2 for NAD(P)(+) Regeneration in Biocatalytic Oxidations
por: Petschacher, Barbara, et al.
Publicado: (2014)

Influence of GSH synthesis inhibition on temporal distribution of NAD+/NADH during vascular endothelial cells proliferation
por: Busu, C, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_jse8gn98flr3o8ds726qhvb12u