Cargando…

Cardiac myosin regulatory light chain kinase modulates cardiac contractility by phosphorylating both myosin regulatory light chain and troponin I

Heart muscle contractility and performance are controlled by posttranslational modifications of sarcomeric proteins. Although myosin regulatory light chain (RLC) phosphorylation has been studied extensively in vitro and in vivo, the precise role of cardiac myosin light chain kinase (cMLCK), the prim...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sevrieva, Ivanka R., Brandmeier, Birgit, Ponnam, Saraswathi, Gautel, Mathias, Irving, Malcolm, Campbell, Kenneth S., Sun, Yin-Biao, Kampourakis, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135997/ https://www.ncbi.nlm.nih.gov/pubmed/32086378 http://dx.doi.org/10.1074/jbc.RA119.011945

Ejemplares similares

Hypertrophic cardiomyopathy mutation R58Q in the myosin regulatory light chain perturbs thick filament-based regulation in cardiac muscle
por: Kampourakis, Thomas, et al.
Publicado: (2018)

Phosphorylation of myosin regulatory light chain controls myosin head conformation in cardiac muscle
por: Kampourakis, Thomas, et al.
Publicado: (2015)

Site-specific phosphorylation of myosin binding protein-C coordinates thin and thick filament activation in cardiac muscle
por: Ponnam, Saraswathi, et al.
Publicado: (2019)

Orientation of the N- and C-Terminal Lobes of the Myosin Regulatory Light Chain in Cardiac Muscle
por: Kampourakis, Thomas, et al.
Publicado: (2015)

Phosphorylation-dependent interactions of myosin-binding protein C and troponin coordinate the myofilament response to protein kinase A
por: Sevrieva, Ivanka R., et al.
Publicado: (2022)

The regulatory light chain mediates inactivation of myosin motors during active shortening of cardiac muscle
por: Kampourakis, Thomas, et al.
Publicado: (2021)

Structural and functional effects of myosin-binding protein-C phosphorylation in heart muscle are not mimicked by serine-to-aspartate substitutions
por: Kampourakis, Thomas, et al.
Publicado: (2018)

Microscale thermophoresis suggests a new model of regulation of cardiac myosin function via interaction with cardiac myosin-binding protein C
por: Ponnam, Saraswathi, et al.
Publicado: (2021)

Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filament
por: Kampourakis, Thomas, et al.
Publicado: (2017)

Regulatory domain of troponin moves dynamically during activation of cardiac muscle
por: Sevrieva, Ivanka, et al.
Publicado: (2014)

Monophosphorylation of cardiac troponin-I at Ser-23/24 is sufficient to regulate cardiac myofibrillar Ca(2+) sensitivity and calpain-induced proteolysis
por: Martin-Garrido, Abel, et al.
Publicado: (2018)

Myosin Regulatory Light Chain (RLC) Phosphorylation Change as a Modulator of Cardiac Muscle Contraction in Disease
por: Toepfer, Christopher, et al.
Publicado: (2013)

Phosphoregulation of the Titin-cap Protein Telethonin in Cardiac Myocytes
por: Candasamy, Alexandra J., et al.
Publicado: (2014)

p90 ribosomal S6 kinase (RSK) phosphorylates myosin phosphatase and thereby controls edge dynamics during cell migration
por: Samson, Shiela C., et al.
Publicado: (2019)

Insulin Inhibits Cardiac Contractility by Inducing a G(i)-Biased β(2)-Adrenergic Signaling in Hearts
por: Fu, Qin, et al.
Publicado: (2014)

Myosin light chain phosphatase catalytic subunit dephosphorylates cardiac myosin via mechanisms dependent and independent of the MYPT regulatory subunits
por: Lee, Eunyoung, et al.
Publicado: (2022)

Structure of Rpn10 and Its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12
por: Riedinger, Christiane, et al.
Publicado: (2010)

Impact of regulatory light chain mutation K104E on the ATPase and motor properties of cardiac myosin
por: Rasicci, David V., et al.
Publicado: (2021)

Phosphorylation of the regulatory light chain of myosin in striated muscle: methodological perspectives
por: Yu, Haiyang, et al.
Publicado: (2016)

Loss of cardiac myosin light chain kinase contributes to contractile dysfunction in right ventricular pressure overload
por: Prasad, Vidhya, et al.
Publicado: (2022)

Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin
por: Hitsumoto, Tatsuro, et al.
Publicado: (2023)

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein–Coupled Receptor FFAR2
por: Tolhurst, Gwen, et al.
Publicado: (2012)

Myosin light chain kinase and myosin light chain phosphatase from Dictyostelium: effects of reversible phosphorylation on myosin structure and function
Publicado: (1987)

Inhibition of the Cardiac Na(+) Channel Nav1.5 by Carbon Monoxide
por: Elies, Jacobo, et al.
Publicado: (2014)

Myosin light chain kinase-driven myosin II turnover regulates actin cortex contractility during mitosis
por: Taneja, Nilay, et al.
Publicado: (2021)

Protein Kinase A Regulatory Subunits in Human Adipose Tissue: Decreased R2B Expression and Activity in Adipocytes From Obese Subjects
por: Mantovani, Giovanna, et al.
Publicado: (2009)

Engineering A-kinase Anchoring Protein (AKAP)-selective Regulatory Subunits of Protein Kinase A (PKA) through Structure-based Phage Selection
por: Gold, Matthew G., et al.
Publicado: (2013)

Phosphorylation of protein kinase A (PKA) regulatory subunit RIα by protein kinase G (PKG) primes PKA for catalytic activity in cells
por: Haushalter, Kristofer J., et al.
Publicado: (2018)

Bond swapping from a charge cloud allows flexible coordination of upstream signals through WASP: Multiple regulatory roles for the WASP basic region
por: Tetley, George J. N., et al.
Publicado: (2018)

Myosin light chain 3F regulatory sequences confer regionalized cardiac and skeletal muscle expression in transgenic mice
Publicado: (1995)

Coupling of ATPase activity and motility in smooth muscle myosin is mediated by the regulatory light chain
Publicado: (1994)

In vivo phosphorylation of regulatory light chain of myosin II during mitosis of cultured cells
Publicado: (1994)

Acceleration of Stretch Activation in Murine Myocardium due to Phosphorylation of Myosin Regulatory Light Chain
por: Stelzer, Julian E., et al.
Publicado: (2006)

The involvement of myosin regulatory light chain diphosphorylation in sustained vasoconstriction under pathophysiological conditions
por: Takeya, Kosuke, et al.
Publicado: (2014)

Divergence of cytokinesis and dimorphism control by myosin II regulatory light chain in fission yeasts
por: Prieto-Ruiz, Francisco, et al.
Publicado: (2023)

Phosphorylation of Rat Melanopsin at Ser-381 and Ser-398 by Light/Dark and Its Importance for Intrinsically Photosensitive Ganglion Cells (ipRGCs) Cellular Ca(2+) Signaling
por: Fahrenkrug, Jan, et al.
Publicado: (2014)

Dilated Cardiomyopathy Mutation (R134W) in Mouse Cardiac Troponin T Induces Greater Contractile Deficits against α-Myosin Heavy Chain than against β-Myosin Heavy Chain
por: Gollapudi, Sampath K., et al.
Publicado: (2016)

Small Molecule AKAP-Protein Kinase A (PKA) Interaction Disruptors That Activate PKA Interfere with Compartmentalized cAMP Signaling in Cardiac Myocytes
por: Christian, Frank, et al.
Publicado: (2011)

The Effects of Neuregulin on Cardiac Myosin Light Chain Kinase Gene-Ablated Hearts
por: Chang, Audrey N., et al.
Publicado: (2013)

Heart Failure Induced by Perinatal Ablation of Cardiac Myosin Light Chain Kinase
por: Islam, Yasmin F. K., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_jfs11jh3f8i0mr9v2it7m7da2s