Nicotinamide mononucleotide adenylyltransferase uses its NAD(+) substrate-binding site to chaperone phosphorylated Tau

Tau hyper-phosphorylation and deposition into neurofibrillary tangles have been found in brains of patients with Alzheimer’s disease (AD) and other tauopathies. Molecular chaperones are involved in regulating the pathological aggregation of phosphorylated Tau (pTau) and modulating disease progressio...

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Detalles Bibliográficos
Autores principales: Ma, Xiaojuan, Zhu, Yi, Lu, Jinxia, Xie, Jingfei, Li, Chong, Shin, Woo Shik, Qiang, Jiali, Liu, Jiaqi, Dou, Shuai, Xiao, Yi, Wang, Chuchu, Jia, Chunyu, Long, Houfang, Yang, Juntao, Fang, Yanshan, Jiang, Lin, Zhang, Yaoyang, Zhang, Shengnan, Zhai, Rong Grace, Liu, Cong, Li, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136026/
https://www.ncbi.nlm.nih.gov/pubmed/32250733
http://dx.doi.org/10.7554/eLife.51859

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