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Cortical topological network changes following optic neuritis
OBJECTIVE: To differentiate between visual cortical network topology changes following optic neuritis (ON) stemming from different inflammatory disease types, we used mathematical graph theory–based tools to analyze functional imaging data. METHODS: Sixty-two patients were recruited into this cross-...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136064/ https://www.ncbi.nlm.nih.gov/pubmed/32123044 http://dx.doi.org/10.1212/NXI.0000000000000687 |
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author | Backner, Yael Ben-Shalom, Ido Kuchling, Joseph Siebert, Nadja Scheel, Michael Ruprecht, Klemens Brandt, Alexander Paul, Friedemann Levin, Netta |
author_facet | Backner, Yael Ben-Shalom, Ido Kuchling, Joseph Siebert, Nadja Scheel, Michael Ruprecht, Klemens Brandt, Alexander Paul, Friedemann Levin, Netta |
author_sort | Backner, Yael |
collection | PubMed |
description | OBJECTIVE: To differentiate between visual cortical network topology changes following optic neuritis (ON) stemming from different inflammatory disease types, we used mathematical graph theory–based tools to analyze functional imaging data. METHODS: Sixty-two patients were recruited into this cross-sectional study, 23 of whom had neuromyelitis optica spectrum disorder (NMOSD) with ON, 18 with clinically isolated syndrome (CIS)-ON, and 21 with other CIS episodes. Twenty-six healthy controls (HCs) were also recruited. All participants underwent resting-state functional MRI. Visual networks were defined using 50 visual regions of interest. Analysis included graph theory metrics, including degree, density, modularity, and local and global efficiency. RESULTS: Visual network density shows decreased connectivity in all patient groups compared with controls. A higher degree of connections is seen in both ON groups (CIS and NMOSD) compared with the the non-ON group. This pattern is most pronounced in dorsal-lateral regions. Information transfer efficiency and modularity were reduced in both CIS groups, but not in the NMOSD group, compared with the HC group. CONCLUSIONS: Visual network density appears affected by the neurologic deficit sustained (ON), and connectivity changes are more evident in dorsal-lateral regions. Efficiency and modularity appear to be associated with the specific disease type (CIS vs NMOSD). Thus, topological cortical changes in the visual system are associated with the type of neurologic deficit within the limits set on them by the underlying pathophysiology. We suggest that cortical patterns of activity should be considered in the outcome of the patients despite the localized nature of ON. |
format | Online Article Text |
id | pubmed-7136064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-71360642020-04-17 Cortical topological network changes following optic neuritis Backner, Yael Ben-Shalom, Ido Kuchling, Joseph Siebert, Nadja Scheel, Michael Ruprecht, Klemens Brandt, Alexander Paul, Friedemann Levin, Netta Neurol Neuroimmunol Neuroinflamm Article OBJECTIVE: To differentiate between visual cortical network topology changes following optic neuritis (ON) stemming from different inflammatory disease types, we used mathematical graph theory–based tools to analyze functional imaging data. METHODS: Sixty-two patients were recruited into this cross-sectional study, 23 of whom had neuromyelitis optica spectrum disorder (NMOSD) with ON, 18 with clinically isolated syndrome (CIS)-ON, and 21 with other CIS episodes. Twenty-six healthy controls (HCs) were also recruited. All participants underwent resting-state functional MRI. Visual networks were defined using 50 visual regions of interest. Analysis included graph theory metrics, including degree, density, modularity, and local and global efficiency. RESULTS: Visual network density shows decreased connectivity in all patient groups compared with controls. A higher degree of connections is seen in both ON groups (CIS and NMOSD) compared with the the non-ON group. This pattern is most pronounced in dorsal-lateral regions. Information transfer efficiency and modularity were reduced in both CIS groups, but not in the NMOSD group, compared with the HC group. CONCLUSIONS: Visual network density appears affected by the neurologic deficit sustained (ON), and connectivity changes are more evident in dorsal-lateral regions. Efficiency and modularity appear to be associated with the specific disease type (CIS vs NMOSD). Thus, topological cortical changes in the visual system are associated with the type of neurologic deficit within the limits set on them by the underlying pathophysiology. We suggest that cortical patterns of activity should be considered in the outcome of the patients despite the localized nature of ON. Lippincott Williams & Wilkins 2020-03-02 /pmc/articles/PMC7136064/ /pubmed/32123044 http://dx.doi.org/10.1212/NXI.0000000000000687 Text en Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Article Backner, Yael Ben-Shalom, Ido Kuchling, Joseph Siebert, Nadja Scheel, Michael Ruprecht, Klemens Brandt, Alexander Paul, Friedemann Levin, Netta Cortical topological network changes following optic neuritis |
title | Cortical topological network changes following optic neuritis |
title_full | Cortical topological network changes following optic neuritis |
title_fullStr | Cortical topological network changes following optic neuritis |
title_full_unstemmed | Cortical topological network changes following optic neuritis |
title_short | Cortical topological network changes following optic neuritis |
title_sort | cortical topological network changes following optic neuritis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136064/ https://www.ncbi.nlm.nih.gov/pubmed/32123044 http://dx.doi.org/10.1212/NXI.0000000000000687 |
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