The UMBRELLA SIOP–RTSG 2016 Wilms tumour pathology and molecular biology protocol

On the basis of the results of previous national and international trials and studies, the Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP–RTSG) has developed a new study protocol for paediatric renal tumours: the UMBRELLA SIOP–RTSG 2016 protocol (the UMBRELLA prot...

Descripción completa

Detalles Bibliográficos
Autores principales: Vujanić, Gordan M., Gessler, Manfred, Ooms, Ariadne H. A. G., Collini, Paola, Coulomb-l’Hermine, Aurore, D’Hooghe, Ellen, de Krijger, Ronald R., Perotti, Daniela, Pritchard-Jones, Kathy, Vokuhl, Christian, van den Heuvel-Eibrink, Marry M., Graf, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Consensus Statement
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136175/
https://www.ncbi.nlm.nih.gov/pubmed/30310143
http://dx.doi.org/10.1038/s41585-018-0100-3
_version_ 1783518192315924480
author Vujanić, Gordan M.
Gessler, Manfred
Ooms, Ariadne H. A. G.
Collini, Paola
Coulomb-l’Hermine, Aurore
D’Hooghe, Ellen
de Krijger, Ronald R.
Perotti, Daniela
Pritchard-Jones, Kathy
Vokuhl, Christian
van den Heuvel-Eibrink, Marry M.
Graf, Norbert
author_facet Vujanić, Gordan M.
Gessler, Manfred
Ooms, Ariadne H. A. G.
Collini, Paola
Coulomb-l’Hermine, Aurore
D’Hooghe, Ellen
de Krijger, Ronald R.
Perotti, Daniela
Pritchard-Jones, Kathy
Vokuhl, Christian
van den Heuvel-Eibrink, Marry M.
Graf, Norbert
author_sort Vujanić, Gordan M.
collection PubMed
description On the basis of the results of previous national and international trials and studies, the Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP–RTSG) has developed a new study protocol for paediatric renal tumours: the UMBRELLA SIOP–RTSG 2016 protocol (the UMBRELLA protocol). Currently, the overall outcomes of patients with Wilms tumour are excellent, but subgroups with poor prognosis and increased relapse rates still exist. The identification of these subgroups is of utmost importance to improve treatment stratification, which might lead to reduction of the direct and late effects of chemotherapy. The UMBRELLA protocol aims to validate new prognostic factors, such as blastemal tumour volume and molecular markers, to further improve outcome. To achieve this aim, large, international, high-quality databases are needed, which dictate optimization and international harmonization of specimen handling and comprehensive sampling of biological material, refine definitions and improve logistics for expert review. To promote broad implementation of the UMBRELLA protocol, the updated SIOP–RTSG pathology and molecular biology protocol for Wilms tumours has been outlined, which is a consensus from the SIOP–RTSG pathology panel.
format Online
Article
Text
id pubmed-7136175
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-71361752020-04-08 The UMBRELLA SIOP–RTSG 2016 Wilms tumour pathology and molecular biology protocol Vujanić, Gordan M. Gessler, Manfred Ooms, Ariadne H. A. G. Collini, Paola Coulomb-l’Hermine, Aurore D’Hooghe, Ellen de Krijger, Ronald R. Perotti, Daniela Pritchard-Jones, Kathy Vokuhl, Christian van den Heuvel-Eibrink, Marry M. Graf, Norbert Nat Rev Urol Consensus Statement On the basis of the results of previous national and international trials and studies, the Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP–RTSG) has developed a new study protocol for paediatric renal tumours: the UMBRELLA SIOP–RTSG 2016 protocol (the UMBRELLA protocol). Currently, the overall outcomes of patients with Wilms tumour are excellent, but subgroups with poor prognosis and increased relapse rates still exist. The identification of these subgroups is of utmost importance to improve treatment stratification, which might lead to reduction of the direct and late effects of chemotherapy. The UMBRELLA protocol aims to validate new prognostic factors, such as blastemal tumour volume and molecular markers, to further improve outcome. To achieve this aim, large, international, high-quality databases are needed, which dictate optimization and international harmonization of specimen handling and comprehensive sampling of biological material, refine definitions and improve logistics for expert review. To promote broad implementation of the UMBRELLA protocol, the updated SIOP–RTSG pathology and molecular biology protocol for Wilms tumours has been outlined, which is a consensus from the SIOP–RTSG pathology panel. Nature Publishing Group UK 2018-10-11 2018 /pmc/articles/PMC7136175/ /pubmed/30310143 http://dx.doi.org/10.1038/s41585-018-0100-3 Text en © The Authors 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Consensus Statement
Vujanić, Gordan M.
Gessler, Manfred
Ooms, Ariadne H. A. G.
Collini, Paola
Coulomb-l’Hermine, Aurore
D’Hooghe, Ellen
de Krijger, Ronald R.
Perotti, Daniela
Pritchard-Jones, Kathy
Vokuhl, Christian
van den Heuvel-Eibrink, Marry M.
Graf, Norbert
The UMBRELLA SIOP–RTSG 2016 Wilms tumour pathology and molecular biology protocol
title The UMBRELLA SIOP–RTSG 2016 Wilms tumour pathology and molecular biology protocol
title_full The UMBRELLA SIOP–RTSG 2016 Wilms tumour pathology and molecular biology protocol
title_fullStr The UMBRELLA SIOP–RTSG 2016 Wilms tumour pathology and molecular biology protocol
title_full_unstemmed The UMBRELLA SIOP–RTSG 2016 Wilms tumour pathology and molecular biology protocol
title_short The UMBRELLA SIOP–RTSG 2016 Wilms tumour pathology and molecular biology protocol
title_sort umbrella siop–rtsg 2016 wilms tumour pathology and molecular biology protocol
topic Consensus Statement
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136175/
https://www.ncbi.nlm.nih.gov/pubmed/30310143
http://dx.doi.org/10.1038/s41585-018-0100-3
work_keys_str_mv AT vujanicgordanm theumbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT gesslermanfred theumbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT oomsariadnehag theumbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT collinipaola theumbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT coulomblhermineaurore theumbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT dhoogheellen theumbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT dekrijgerronaldr theumbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT perottidaniela theumbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT pritchardjoneskathy theumbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT vokuhlchristian theumbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT vandenheuveleibrinkmarrym theumbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT grafnorbert theumbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT theumbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT vujanicgordanm umbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT gesslermanfred umbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT oomsariadnehag umbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT collinipaola umbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT coulomblhermineaurore umbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT dhoogheellen umbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT dekrijgerronaldr umbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT perottidaniela umbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT pritchardjoneskathy umbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT vokuhlchristian umbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT vandenheuveleibrinkmarrym umbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT grafnorbert umbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol
AT umbrellasioprtsg2016wilmstumourpathologyandmolecularbiologyprotocol

Ejemplares similares