Cargando…
Dynamic genome evolution and complex virocell metabolism of globally-distributed giant viruses
The discovery of eukaryotic giant viruses has transformed our understanding of the limits of viral complexity, but the extent of their encoded metabolic diversity remains unclear. Here we generate 501 metagenome-assembled genomes of Nucleo-Cytoplasmic Large DNA Viruses (NCLDV) from environments arou...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136201/ https://www.ncbi.nlm.nih.gov/pubmed/32249765 http://dx.doi.org/10.1038/s41467-020-15507-2 |
_version_ | 1783518198024372224 |
---|---|
author | Moniruzzaman, Mohammad Martinez-Gutierrez, Carolina A. Weinheimer, Alaina R. Aylward, Frank O. |
author_facet | Moniruzzaman, Mohammad Martinez-Gutierrez, Carolina A. Weinheimer, Alaina R. Aylward, Frank O. |
author_sort | Moniruzzaman, Mohammad |
collection | PubMed |
description | The discovery of eukaryotic giant viruses has transformed our understanding of the limits of viral complexity, but the extent of their encoded metabolic diversity remains unclear. Here we generate 501 metagenome-assembled genomes of Nucleo-Cytoplasmic Large DNA Viruses (NCLDV) from environments around the globe, and analyze their encoded functional capacity. We report a remarkable diversity of metabolic genes in widespread giant viruses, including many involved in nutrient uptake, light harvesting, and nitrogen metabolism. Surprisingly, numerous NCLDV encode the components of glycolysis and the TCA cycle, suggesting that they can re-program fundamental aspects of their host’s central carbon metabolism. Our phylogenetic analysis of NCLDV metabolic genes and their cellular homologs reveals distinct clustering of viral sequences into divergent clades, indicating that these genes are virus-specific and were acquired in the distant past. Overall our findings reveal that giant viruses encode complex metabolic capabilities with evolutionary histories largely independent of cellular life, strongly implicating them as important drivers of global biogeochemical cycles. |
format | Online Article Text |
id | pubmed-7136201 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-71362012020-04-08 Dynamic genome evolution and complex virocell metabolism of globally-distributed giant viruses Moniruzzaman, Mohammad Martinez-Gutierrez, Carolina A. Weinheimer, Alaina R. Aylward, Frank O. Nat Commun Article The discovery of eukaryotic giant viruses has transformed our understanding of the limits of viral complexity, but the extent of their encoded metabolic diversity remains unclear. Here we generate 501 metagenome-assembled genomes of Nucleo-Cytoplasmic Large DNA Viruses (NCLDV) from environments around the globe, and analyze their encoded functional capacity. We report a remarkable diversity of metabolic genes in widespread giant viruses, including many involved in nutrient uptake, light harvesting, and nitrogen metabolism. Surprisingly, numerous NCLDV encode the components of glycolysis and the TCA cycle, suggesting that they can re-program fundamental aspects of their host’s central carbon metabolism. Our phylogenetic analysis of NCLDV metabolic genes and their cellular homologs reveals distinct clustering of viral sequences into divergent clades, indicating that these genes are virus-specific and were acquired in the distant past. Overall our findings reveal that giant viruses encode complex metabolic capabilities with evolutionary histories largely independent of cellular life, strongly implicating them as important drivers of global biogeochemical cycles. Nature Publishing Group UK 2020-04-06 /pmc/articles/PMC7136201/ /pubmed/32249765 http://dx.doi.org/10.1038/s41467-020-15507-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Moniruzzaman, Mohammad Martinez-Gutierrez, Carolina A. Weinheimer, Alaina R. Aylward, Frank O. Dynamic genome evolution and complex virocell metabolism of globally-distributed giant viruses |
title | Dynamic genome evolution and complex virocell metabolism of globally-distributed giant viruses |
title_full | Dynamic genome evolution and complex virocell metabolism of globally-distributed giant viruses |
title_fullStr | Dynamic genome evolution and complex virocell metabolism of globally-distributed giant viruses |
title_full_unstemmed | Dynamic genome evolution and complex virocell metabolism of globally-distributed giant viruses |
title_short | Dynamic genome evolution and complex virocell metabolism of globally-distributed giant viruses |
title_sort | dynamic genome evolution and complex virocell metabolism of globally-distributed giant viruses |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136201/ https://www.ncbi.nlm.nih.gov/pubmed/32249765 http://dx.doi.org/10.1038/s41467-020-15507-2 |
work_keys_str_mv | AT moniruzzamanmohammad dynamicgenomeevolutionandcomplexvirocellmetabolismofgloballydistributedgiantviruses AT martinezgutierrezcarolinaa dynamicgenomeevolutionandcomplexvirocellmetabolismofgloballydistributedgiantviruses AT weinheimeralainar dynamicgenomeevolutionandcomplexvirocellmetabolismofgloballydistributedgiantviruses AT aylwardfranko dynamicgenomeevolutionandcomplexvirocellmetabolismofgloballydistributedgiantviruses |