Stress will kill you anyway!

Adrenocortical carcinomas are devastating cancers, expressing high levels of glutathione peroxidase 4 (GPX4). Therefore, it was recently suggested that these tumors might be therapeutically targeted by inducing ferroptosis. In this issue of Cell Death and Disease, Weigand et al. describe the organ-s...

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Detalles Bibliográficos
Autores principales: Belavgeni, Alexia, Bornstein, Stefan R., Linkermann, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136258/
https://www.ncbi.nlm.nih.gov/pubmed/32249778
http://dx.doi.org/10.1038/s41419-020-2433-0
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author Belavgeni, Alexia
Bornstein, Stefan R.
Linkermann, Andreas
author_facet Belavgeni, Alexia
Bornstein, Stefan R.
Linkermann, Andreas
author_sort Belavgeni, Alexia
collection PubMed
description Adrenocortical carcinomas are devastating cancers, expressing high levels of glutathione peroxidase 4 (GPX4). Therefore, it was recently suggested that these tumors might be therapeutically targeted by inducing ferroptosis. In this issue of Cell Death and Disease, Weigand et al. describe the organ-specific production of steroid hormones as a potential culprit for the exquisite sensitivity of these cancers to ferroptosis.
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spelling pubmed-71362582020-04-08 Stress will kill you anyway! Belavgeni, Alexia Bornstein, Stefan R. Linkermann, Andreas Cell Death Dis Editorial Adrenocortical carcinomas are devastating cancers, expressing high levels of glutathione peroxidase 4 (GPX4). Therefore, it was recently suggested that these tumors might be therapeutically targeted by inducing ferroptosis. In this issue of Cell Death and Disease, Weigand et al. describe the organ-specific production of steroid hormones as a potential culprit for the exquisite sensitivity of these cancers to ferroptosis. Nature Publishing Group UK 2020-04-06 /pmc/articles/PMC7136258/ /pubmed/32249778 http://dx.doi.org/10.1038/s41419-020-2433-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Editorial
Belavgeni, Alexia
Bornstein, Stefan R.
Linkermann, Andreas
Stress will kill you anyway!
title Stress will kill you anyway!
title_full Stress will kill you anyway!
title_fullStr Stress will kill you anyway!
title_full_unstemmed Stress will kill you anyway!
title_short Stress will kill you anyway!
title_sort stress will kill you anyway!
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136258/
https://www.ncbi.nlm.nih.gov/pubmed/32249778
http://dx.doi.org/10.1038/s41419-020-2433-0
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