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Cardiac changes in children hospitalized with severe acute malnutrition: A prospective study at tertiary care center of northern India

Severe acute malnutrition (SAM) may affect cardiac structure and function. Cardiac changes in sick children with SAM have received little attention in the literature. Children aged 6–60 months with SAM were cases, and age and sex matched children were controls. Cardiac biomarker levels were measured...

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Autores principales: Jain, Dharmendra, Rao, Sunil Kumar, Kumar, Dhilip, Kumar, Ashok, Sihag, Bhupendra Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136354/
https://www.ncbi.nlm.nih.gov/pubmed/32248924
http://dx.doi.org/10.1016/j.ihj.2020.01.005
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author Jain, Dharmendra
Rao, Sunil Kumar
Kumar, Dhilip
Kumar, Ashok
Sihag, Bhupendra Kumar
author_facet Jain, Dharmendra
Rao, Sunil Kumar
Kumar, Dhilip
Kumar, Ashok
Sihag, Bhupendra Kumar
author_sort Jain, Dharmendra
collection PubMed
description Severe acute malnutrition (SAM) may affect cardiac structure and function. Cardiac changes in sick children with SAM have received little attention in the literature. Children aged 6–60 months with SAM were cases, and age and sex matched children were controls. Cardiac biomarker levels were measured by the quantitative the Enzyme- linked immunosorbent assay (ELISA) method, and echocardiography was used to assess cardiac changes in all children. The study included 76 children in each group. Children with SAM had less left ventricular mass and increased myocardial performance index as compared with controls (p < 0.0001). Cardiac biomarker levels were increased in children with SAM (p < 0.0001). Cardiac changes and biomarker levels were comparable in children with edema and children without edema except creatine kinase-MB (p = 0.01).
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spelling pubmed-71363542020-11-01 Cardiac changes in children hospitalized with severe acute malnutrition: A prospective study at tertiary care center of northern India Jain, Dharmendra Rao, Sunil Kumar Kumar, Dhilip Kumar, Ashok Sihag, Bhupendra Kumar Indian Heart J Research Brief Severe acute malnutrition (SAM) may affect cardiac structure and function. Cardiac changes in sick children with SAM have received little attention in the literature. Children aged 6–60 months with SAM were cases, and age and sex matched children were controls. Cardiac biomarker levels were measured by the quantitative the Enzyme- linked immunosorbent assay (ELISA) method, and echocardiography was used to assess cardiac changes in all children. The study included 76 children in each group. Children with SAM had less left ventricular mass and increased myocardial performance index as compared with controls (p < 0.0001). Cardiac biomarker levels were increased in children with SAM (p < 0.0001). Cardiac changes and biomarker levels were comparable in children with edema and children without edema except creatine kinase-MB (p = 0.01). Elsevier 2019 2020-02-04 /pmc/articles/PMC7136354/ /pubmed/32248924 http://dx.doi.org/10.1016/j.ihj.2020.01.005 Text en © 2020 Cardiological Society of India. Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Brief
Jain, Dharmendra
Rao, Sunil Kumar
Kumar, Dhilip
Kumar, Ashok
Sihag, Bhupendra Kumar
Cardiac changes in children hospitalized with severe acute malnutrition: A prospective study at tertiary care center of northern India
title Cardiac changes in children hospitalized with severe acute malnutrition: A prospective study at tertiary care center of northern India
title_full Cardiac changes in children hospitalized with severe acute malnutrition: A prospective study at tertiary care center of northern India
title_fullStr Cardiac changes in children hospitalized with severe acute malnutrition: A prospective study at tertiary care center of northern India
title_full_unstemmed Cardiac changes in children hospitalized with severe acute malnutrition: A prospective study at tertiary care center of northern India
title_short Cardiac changes in children hospitalized with severe acute malnutrition: A prospective study at tertiary care center of northern India
title_sort cardiac changes in children hospitalized with severe acute malnutrition: a prospective study at tertiary care center of northern india
topic Research Brief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136354/
https://www.ncbi.nlm.nih.gov/pubmed/32248924
http://dx.doi.org/10.1016/j.ihj.2020.01.005
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