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Basic and Clinical Pharmaco-Therapeutics of SGLT2 Inhibitors: A Contemporary Update
Clinical relevance of sodium/glucose cotransporter 2 (SGLT2) inhibitors has been rapidly evolving across several therapy areas, apart from type 2 diabetes mellitus. While some of these developments are based on recognized scientific explanations, unexpected study findings have also shaped much of ou...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Healthcare
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136386/ https://www.ncbi.nlm.nih.gov/pubmed/32130664 http://dx.doi.org/10.1007/s13300-020-00789-y |
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author | Kalra, Sanjay Shetty, Kimi K. Nagarajan, Vertivel B. Ved, Jignesh K. |
author_facet | Kalra, Sanjay Shetty, Kimi K. Nagarajan, Vertivel B. Ved, Jignesh K. |
author_sort | Kalra, Sanjay |
collection | PubMed |
description | Clinical relevance of sodium/glucose cotransporter 2 (SGLT2) inhibitors has been rapidly evolving across several therapy areas, apart from type 2 diabetes mellitus. While some of these developments are based on recognized scientific explanations, unexpected study findings have also shaped much of our present understanding. As the role of these agents evolves in various facets of cardiology, nephrology, hepatology and endocrinology, their optimum clinical value propositions should be realized in line with the principles of personalized medicine. An updated pharmaco-ergonomic qualification tool, based on the present evidence with these agents, would be a step in this direction. This review describes the present evidence on diverse pharmacological and therapeutic aspects for various SGLT2 inhibitors, as an attempt to provide useful guidance for optimum application in clinical practice. |
format | Online Article Text |
id | pubmed-7136386 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-71363862020-04-09 Basic and Clinical Pharmaco-Therapeutics of SGLT2 Inhibitors: A Contemporary Update Kalra, Sanjay Shetty, Kimi K. Nagarajan, Vertivel B. Ved, Jignesh K. Diabetes Ther Review Clinical relevance of sodium/glucose cotransporter 2 (SGLT2) inhibitors has been rapidly evolving across several therapy areas, apart from type 2 diabetes mellitus. While some of these developments are based on recognized scientific explanations, unexpected study findings have also shaped much of our present understanding. As the role of these agents evolves in various facets of cardiology, nephrology, hepatology and endocrinology, their optimum clinical value propositions should be realized in line with the principles of personalized medicine. An updated pharmaco-ergonomic qualification tool, based on the present evidence with these agents, would be a step in this direction. This review describes the present evidence on diverse pharmacological and therapeutic aspects for various SGLT2 inhibitors, as an attempt to provide useful guidance for optimum application in clinical practice. Springer Healthcare 2020-03-04 2020-04 /pmc/articles/PMC7136386/ /pubmed/32130664 http://dx.doi.org/10.1007/s13300-020-00789-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Review Kalra, Sanjay Shetty, Kimi K. Nagarajan, Vertivel B. Ved, Jignesh K. Basic and Clinical Pharmaco-Therapeutics of SGLT2 Inhibitors: A Contemporary Update |
title | Basic and Clinical Pharmaco-Therapeutics of SGLT2 Inhibitors: A Contemporary Update |
title_full | Basic and Clinical Pharmaco-Therapeutics of SGLT2 Inhibitors: A Contemporary Update |
title_fullStr | Basic and Clinical Pharmaco-Therapeutics of SGLT2 Inhibitors: A Contemporary Update |
title_full_unstemmed | Basic and Clinical Pharmaco-Therapeutics of SGLT2 Inhibitors: A Contemporary Update |
title_short | Basic and Clinical Pharmaco-Therapeutics of SGLT2 Inhibitors: A Contemporary Update |
title_sort | basic and clinical pharmaco-therapeutics of sglt2 inhibitors: a contemporary update |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136386/ https://www.ncbi.nlm.nih.gov/pubmed/32130664 http://dx.doi.org/10.1007/s13300-020-00789-y |
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