An Occult HPV-Driven Oropharyngeal Squamous Cell Carcinoma Discovered Through a Saliva Test

Oropharyngeal cancer (OPC) caused by human papillomavirus (HPV) is a rising global concern. Early lesions are small and are often located in difficult to access areas (such as the crypts of the tonsils or base of tongue). Unlike cervical cancer, there is no standard or routine screening program for...

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Autores principales: Tang, Kai Dun, Vasani, Sarju, Taheri, Touraj, Walsh, Laurence J., Hughes, Brett G. M., Kenny, Lizbeth, Punyadeera, Chamindie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136454/
https://www.ncbi.nlm.nih.gov/pubmed/32296641
http://dx.doi.org/10.3389/fonc.2020.00408
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author Tang, Kai Dun
Vasani, Sarju
Taheri, Touraj
Walsh, Laurence J.
Hughes, Brett G. M.
Kenny, Lizbeth
Punyadeera, Chamindie
author_facet Tang, Kai Dun
Vasani, Sarju
Taheri, Touraj
Walsh, Laurence J.
Hughes, Brett G. M.
Kenny, Lizbeth
Punyadeera, Chamindie
author_sort Tang, Kai Dun
collection PubMed
description Oropharyngeal cancer (OPC) caused by human papillomavirus (HPV) is a rising global concern. Early lesions are small and are often located in difficult to access areas (such as the crypts of the tonsils or base of tongue). Unlike cervical cancer, there is no standard or routine screening program for HPV-driven OPC. HPV DNA from OPC tumors may shed directly into saliva, and this can be used as a biomarker for early diagnosis. In this study, we report the first-ever clinically occult OPC in an asymptomatic patient discovered through a saliva test. This case relied upon serial measurements of HPV-16 DNA in saliva, which fell to undetectable levels following low morbidity, curative treatment.
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spelling pubmed-71364542020-04-15 An Occult HPV-Driven Oropharyngeal Squamous Cell Carcinoma Discovered Through a Saliva Test Tang, Kai Dun Vasani, Sarju Taheri, Touraj Walsh, Laurence J. Hughes, Brett G. M. Kenny, Lizbeth Punyadeera, Chamindie Front Oncol Oncology Oropharyngeal cancer (OPC) caused by human papillomavirus (HPV) is a rising global concern. Early lesions are small and are often located in difficult to access areas (such as the crypts of the tonsils or base of tongue). Unlike cervical cancer, there is no standard or routine screening program for HPV-driven OPC. HPV DNA from OPC tumors may shed directly into saliva, and this can be used as a biomarker for early diagnosis. In this study, we report the first-ever clinically occult OPC in an asymptomatic patient discovered through a saliva test. This case relied upon serial measurements of HPV-16 DNA in saliva, which fell to undetectable levels following low morbidity, curative treatment. Frontiers Media S.A. 2020-03-31 /pmc/articles/PMC7136454/ /pubmed/32296641 http://dx.doi.org/10.3389/fonc.2020.00408 Text en Copyright © 2020 Tang, Vasani, Taheri, Walsh, Hughes, Kenny and Punyadeera. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Tang, Kai Dun
Vasani, Sarju
Taheri, Touraj
Walsh, Laurence J.
Hughes, Brett G. M.
Kenny, Lizbeth
Punyadeera, Chamindie
An Occult HPV-Driven Oropharyngeal Squamous Cell Carcinoma Discovered Through a Saliva Test
title An Occult HPV-Driven Oropharyngeal Squamous Cell Carcinoma Discovered Through a Saliva Test
title_full An Occult HPV-Driven Oropharyngeal Squamous Cell Carcinoma Discovered Through a Saliva Test
title_fullStr An Occult HPV-Driven Oropharyngeal Squamous Cell Carcinoma Discovered Through a Saliva Test
title_full_unstemmed An Occult HPV-Driven Oropharyngeal Squamous Cell Carcinoma Discovered Through a Saliva Test
title_short An Occult HPV-Driven Oropharyngeal Squamous Cell Carcinoma Discovered Through a Saliva Test
title_sort occult hpv-driven oropharyngeal squamous cell carcinoma discovered through a saliva test
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136454/
https://www.ncbi.nlm.nih.gov/pubmed/32296641
http://dx.doi.org/10.3389/fonc.2020.00408
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