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Integrated Data Analysis of Six Clinical Studies Points Toward Model-Informed Precision Dosing of Tamoxifen

INTRODUCTION: At tamoxifen standard dosing, ∼20% of breast cancer patients do not reach proposed target endoxifen concentrations >5.97 ng/mL. Thus, better understanding the large interindividual variability in tamoxifen pharmacokinetics (PK) is crucial. By applying non-linear mixed-effects (NLME)...

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Detalles Bibliográficos
Autores principales:	Klopp-Schulze, Lena, Mueller-Schoell, Anna, Neven, Patrick, Koolen, Stijn L. W., Mathijssen, Ron H. J., Joerger, Markus, Kloft, Charlotte
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136483/ https://www.ncbi.nlm.nih.gov/pubmed/32296331 http://dx.doi.org/10.3389/fphar.2020.00283

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