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Effect of -202 A/C IGFBP-3 polymorphisms on growth responses in children with idiopathic short stature
PURPOSE: This study evaluated the -202 A/C insulin-like growth factor binding protein 3 (IGFBP-3) promoter polymorphism as a predictor of serum IGFBP-3 concentration and growth velocity after recombinant growth hormone (rhGH) therapy in patients with idiopathic short stature (ISS). METHODS: Genotypi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Pediatric Endocrinology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136511/ https://www.ncbi.nlm.nih.gov/pubmed/32252214 http://dx.doi.org/10.6065/apem.2020.25.1.31 |
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author | Kang, Hye Ree Hwang, Il Tae Yang, Seung |
author_facet | Kang, Hye Ree Hwang, Il Tae Yang, Seung |
author_sort | Kang, Hye Ree |
collection | PubMed |
description | PURPOSE: This study evaluated the -202 A/C insulin-like growth factor binding protein 3 (IGFBP-3) promoter polymorphism as a predictor of serum IGFBP-3 concentration and growth velocity after recombinant growth hormone (rhGH) therapy in patients with idiopathic short stature (ISS). METHODS: Genotyping and serial measurement of clinical parameters were performed in 69 children with a confirmed diagnosis of ISS. Restriction fragment length polymorphism analysis was performed to determine the genotype at the -202 IGFBP-3 locus. Serum insulin-like growth factor 1 (IGF-1) and IGFBP-3 levels were measured at baseline and after 1 year of rhGH treatment, as were height standard deviation score and growth velocity. RESULTS: The -202 A/C IGFBP-3 genotype comprised 69.6% AA, 24.6% AC, and 5.8% CC. One year of treatment did not produce a meaningful difference in IGF-1 or IGFBP-3 levels between children in the AA group and those with at least one copy of the C allele (AC/CC group). Comparing the 2 groups after one year also revealed no significant difference in growth velocity (ΔHeight: 9.061±1.612 cm/yr in the AA group, 9.421±1.864 in the AC/CC group, P=0.419). CONCLUSIONS: rhGH treatment was effective and there were no significant differences in IGF-1, IGFBP-3, or growth velocity according to genotype. Thus, -202 IGFBP-3 genotype may not be a major factor affecting individual growth responses in Korean children with ISS. |
format | Online Article Text |
id | pubmed-7136511 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Korean Society of Pediatric Endocrinology |
record_format | MEDLINE/PubMed |
spelling | pubmed-71365112020-04-10 Effect of -202 A/C IGFBP-3 polymorphisms on growth responses in children with idiopathic short stature Kang, Hye Ree Hwang, Il Tae Yang, Seung Ann Pediatr Endocrinol Metab Original Article PURPOSE: This study evaluated the -202 A/C insulin-like growth factor binding protein 3 (IGFBP-3) promoter polymorphism as a predictor of serum IGFBP-3 concentration and growth velocity after recombinant growth hormone (rhGH) therapy in patients with idiopathic short stature (ISS). METHODS: Genotyping and serial measurement of clinical parameters were performed in 69 children with a confirmed diagnosis of ISS. Restriction fragment length polymorphism analysis was performed to determine the genotype at the -202 IGFBP-3 locus. Serum insulin-like growth factor 1 (IGF-1) and IGFBP-3 levels were measured at baseline and after 1 year of rhGH treatment, as were height standard deviation score and growth velocity. RESULTS: The -202 A/C IGFBP-3 genotype comprised 69.6% AA, 24.6% AC, and 5.8% CC. One year of treatment did not produce a meaningful difference in IGF-1 or IGFBP-3 levels between children in the AA group and those with at least one copy of the C allele (AC/CC group). Comparing the 2 groups after one year also revealed no significant difference in growth velocity (ΔHeight: 9.061±1.612 cm/yr in the AA group, 9.421±1.864 in the AC/CC group, P=0.419). CONCLUSIONS: rhGH treatment was effective and there were no significant differences in IGF-1, IGFBP-3, or growth velocity according to genotype. Thus, -202 IGFBP-3 genotype may not be a major factor affecting individual growth responses in Korean children with ISS. Korean Society of Pediatric Endocrinology 2020-03 2020-03-31 /pmc/articles/PMC7136511/ /pubmed/32252214 http://dx.doi.org/10.6065/apem.2020.25.1.31 Text en © 2020 Annals of Pediatric Endocrinology & Metabolism This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kang, Hye Ree Hwang, Il Tae Yang, Seung Effect of -202 A/C IGFBP-3 polymorphisms on growth responses in children with idiopathic short stature |
title | Effect of -202 A/C IGFBP-3 polymorphisms on growth responses in children with idiopathic short stature |
title_full | Effect of -202 A/C IGFBP-3 polymorphisms on growth responses in children with idiopathic short stature |
title_fullStr | Effect of -202 A/C IGFBP-3 polymorphisms on growth responses in children with idiopathic short stature |
title_full_unstemmed | Effect of -202 A/C IGFBP-3 polymorphisms on growth responses in children with idiopathic short stature |
title_short | Effect of -202 A/C IGFBP-3 polymorphisms on growth responses in children with idiopathic short stature |
title_sort | effect of -202 a/c igfbp-3 polymorphisms on growth responses in children with idiopathic short stature |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136511/ https://www.ncbi.nlm.nih.gov/pubmed/32252214 http://dx.doi.org/10.6065/apem.2020.25.1.31 |
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