BTLA-Expressing Dendritic Cells in Patients With Tuberculosis Exhibit Reduced Production of IL-12/IFN-α and Increased Production of IL-4 and TGF-β, Favoring Th2 and Foxp3(+) Treg Polarization

Little is known about how tuberculosis (TB) impairs dendritic cell (DC) function and anti-TB immune responses. We previously showed that the B and T lymphocyte attenuator (BTLA), an immune inhibitory receptor, is involved in TB pathogenesis. Here, we examined whether BTLA expression in TB affects ph...

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Detalles Bibliográficos
Autores principales: Zhang, Jun-Ai, Lu, Yuan-Bin, Wang, Wan-Dang, Liu, Gan-Bin, Chen, Chen, Shen, Ling, Luo, Hou-Long, Xu, Huan, Peng, Ying, Luo, Hong, Huang, Gui-Xian, Wu, Du-Du, Zheng, Bi-Ying, Yi, Lai-Long, Chen, Zheng W., Xu, Jun-Fa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136538/
https://www.ncbi.nlm.nih.gov/pubmed/32296431
http://dx.doi.org/10.3389/fimmu.2020.00518

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