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Assessment of the Role of C3(H(2)O) in the Alternative Pathway

In this study we investigate the hydrolysis of C3 to C3(H(2)O) and its ability to initiate activation via the alternative pathway (AP) of the complement system. The internal thioester bond within C3 is hydrolyzed by water in plasma because of its inherent lability. This results in the formation of n...

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Detalles Bibliográficos
Autores principales:	Fromell, Karin, Adler, Anna, Åman, Amanda, Manivel, Vivek Anand, Huang, Shan, Dührkop, Claudia, Sandholm, Kerstin, Ekdahl, Kristina N., Nilsson, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136553/ https://www.ncbi.nlm.nih.gov/pubmed/32296436 http://dx.doi.org/10.3389/fimmu.2020.00530

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