A Novel Tau Antibody Detecting the First Amino-Terminal Insert Reveals Conformational Differences Among Tau Isoforms

As human Tau undergoes pathologically relevant post-translational modifications when expressed in yeast, the use of humanized yeast models for the generation of novel Tau monoclonal antibodies has previously been proven to be successful. In this study, human Tau2N4R-ΔK280 purified from yeast was use...

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Detalles Bibliográficos
Autores principales: Verelst, Joke, Geukens, Nick, Eddarkaoui, Sabiha, Vliegen, Dorien, De Smidt, Elien, Rosseels, Joëlle, Franssens, Vanessa, Molenberghs, Sofie, Francois, Cindy, Stoops, Erik, Bjerke, Maria, Engelborghs, Sebastiaan, Laghmouchi, Mohamed, Carmans, Sofie, Buée, Luc, Vanmechelen, Eugeen, Winderickx, Joris, Thomas, Debby
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136581/
https://www.ncbi.nlm.nih.gov/pubmed/32296712
http://dx.doi.org/10.3389/fmolb.2020.00048

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