MDM2 Inhibition in a Subset of Sarcoma Cell Lines Increases Susceptibility to Radiation Therapy by Inducing Senescence in the Polyploid Cells

PURPOSE: Inhibition of p53 by amplification of MDM2 is one of the key contributors in the oncogenesis of a subset of soft tissue sarcoma (STS) known as well-/dedifferentiated liposarcoma. A small molecule MDM2 antagonist, nutlin-3, induces the p53 pathway by disrupting the interaction between MDM2 a...

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Detalles Bibliográficos
Autor principal: Das, Samayita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Biology Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136631/
https://www.ncbi.nlm.nih.gov/pubmed/32280825
http://dx.doi.org/10.1016/j.adro.2019.11.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136631/
https://www.ncbi.nlm.nih.gov/pubmed/32280825
http://dx.doi.org/10.1016/j.adro.2019.11.004

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