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A Sudden Onset of Severe Thrombocytopenia While Using Evolocumab
A 72-year-old man with a 10-year history of coronary heart disease started evolocumab treatment once a month after developing excess myalgia due to therapy with a 3-hydroxy-methylglutaryl CoA reductase inhibitor. No side effects such as myalgia symptoms had been reported during the first 14 months o...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136763/ https://www.ncbi.nlm.nih.gov/pubmed/32274224 http://dx.doi.org/10.1155/2020/3281626 |
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author | Inoue, Ikuo Takenaka, Yasuhiro Kin, Yoshitora Yamazaki, Satoshi Ikegami, Yuichi Saito, Daigo Shimada, Akira |
author_facet | Inoue, Ikuo Takenaka, Yasuhiro Kin, Yoshitora Yamazaki, Satoshi Ikegami, Yuichi Saito, Daigo Shimada, Akira |
author_sort | Inoue, Ikuo |
collection | PubMed |
description | A 72-year-old man with a 10-year history of coronary heart disease started evolocumab treatment once a month after developing excess myalgia due to therapy with a 3-hydroxy-methylglutaryl CoA reductase inhibitor. No side effects such as myalgia symptoms had been reported during the first 14 months of evolocumab treatment; however, he suddenly presented with acute severe thrombocytopenia following the 14th treatment. His platelet count continued to decrease to a nadir of 1,000/μL. His platelet-associated immunoglobulin G level had elevated to 790 ng/10(7) cells. He started receiving a combination of steroid therapy, high-dose immunoglobulin therapy, and platelet transfusions, but the first-line therapy was ineffective. He was subsequently treated with a thrombopoietin receptor agonist, and his platelet count recovered to 250,000/μL. |
format | Online Article Text |
id | pubmed-7136763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-71367632020-04-09 A Sudden Onset of Severe Thrombocytopenia While Using Evolocumab Inoue, Ikuo Takenaka, Yasuhiro Kin, Yoshitora Yamazaki, Satoshi Ikegami, Yuichi Saito, Daigo Shimada, Akira Case Rep Hematol Case Report A 72-year-old man with a 10-year history of coronary heart disease started evolocumab treatment once a month after developing excess myalgia due to therapy with a 3-hydroxy-methylglutaryl CoA reductase inhibitor. No side effects such as myalgia symptoms had been reported during the first 14 months of evolocumab treatment; however, he suddenly presented with acute severe thrombocytopenia following the 14th treatment. His platelet count continued to decrease to a nadir of 1,000/μL. His platelet-associated immunoglobulin G level had elevated to 790 ng/10(7) cells. He started receiving a combination of steroid therapy, high-dose immunoglobulin therapy, and platelet transfusions, but the first-line therapy was ineffective. He was subsequently treated with a thrombopoietin receptor agonist, and his platelet count recovered to 250,000/μL. Hindawi 2020-03-26 /pmc/articles/PMC7136763/ /pubmed/32274224 http://dx.doi.org/10.1155/2020/3281626 Text en Copyright © 2020 Ikuo Inoue et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Inoue, Ikuo Takenaka, Yasuhiro Kin, Yoshitora Yamazaki, Satoshi Ikegami, Yuichi Saito, Daigo Shimada, Akira A Sudden Onset of Severe Thrombocytopenia While Using Evolocumab |
title | A Sudden Onset of Severe Thrombocytopenia While Using Evolocumab |
title_full | A Sudden Onset of Severe Thrombocytopenia While Using Evolocumab |
title_fullStr | A Sudden Onset of Severe Thrombocytopenia While Using Evolocumab |
title_full_unstemmed | A Sudden Onset of Severe Thrombocytopenia While Using Evolocumab |
title_short | A Sudden Onset of Severe Thrombocytopenia While Using Evolocumab |
title_sort | sudden onset of severe thrombocytopenia while using evolocumab |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136763/ https://www.ncbi.nlm.nih.gov/pubmed/32274224 http://dx.doi.org/10.1155/2020/3281626 |
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