Cargando…

Association of Healthy Lifestyle With Years Lived Without Major Chronic Diseases

IMPORTANCE: It is well established that selected lifestyle factors are individually associated with lower risk of chronic diseases, but how combinations of these factors are associated with disease-free life-years is unknown. OBJECTIVE: To estimate the association between healthy lifestyle and the n...

Descripción completa

Detalles Bibliográficos
Autores principales: Nyberg, Solja T., Singh-Manoux, Archana, Pentti, Jaana, Madsen, Ida E. H., Sabia, Severine, Alfredsson, Lars, Bjorner, Jakob B., Borritz, Marianne, Burr, Hermann, Goldberg, Marcel, Heikkilä, Katriina, Jokela, Markus, Knutsson, Anders, Lallukka, Tea, Lindbohm, Joni V., Nielsen, Martin L., Nordin, Maria, Oksanen, Tuula, Pejtersen, Jan H., Rahkonen, Ossi, Rugulies, Reiner, Shipley, Martin J., Sipilä, Pyry N., Stenholm, Sari, Suominen, Sakari, Vahtera, Jussi, Virtanen, Marianna, Westerlund, Hugo, Zins, Marie, Hamer, Mark, Batty, G. David, Kivimäki, Mika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136858/
https://www.ncbi.nlm.nih.gov/pubmed/32250383
http://dx.doi.org/10.1001/jamainternmed.2020.0618
_version_ 1783518329863929856
author Nyberg, Solja T.
Singh-Manoux, Archana
Pentti, Jaana
Madsen, Ida E. H.
Sabia, Severine
Alfredsson, Lars
Bjorner, Jakob B.
Borritz, Marianne
Burr, Hermann
Goldberg, Marcel
Heikkilä, Katriina
Jokela, Markus
Knutsson, Anders
Lallukka, Tea
Lindbohm, Joni V.
Nielsen, Martin L.
Nordin, Maria
Oksanen, Tuula
Pejtersen, Jan H.
Rahkonen, Ossi
Rugulies, Reiner
Shipley, Martin J.
Sipilä, Pyry N.
Stenholm, Sari
Suominen, Sakari
Vahtera, Jussi
Virtanen, Marianna
Westerlund, Hugo
Zins, Marie
Hamer, Mark
Batty, G. David
Kivimäki, Mika
author_facet Nyberg, Solja T.
Singh-Manoux, Archana
Pentti, Jaana
Madsen, Ida E. H.
Sabia, Severine
Alfredsson, Lars
Bjorner, Jakob B.
Borritz, Marianne
Burr, Hermann
Goldberg, Marcel
Heikkilä, Katriina
Jokela, Markus
Knutsson, Anders
Lallukka, Tea
Lindbohm, Joni V.
Nielsen, Martin L.
Nordin, Maria
Oksanen, Tuula
Pejtersen, Jan H.
Rahkonen, Ossi
Rugulies, Reiner
Shipley, Martin J.
Sipilä, Pyry N.
Stenholm, Sari
Suominen, Sakari
Vahtera, Jussi
Virtanen, Marianna
Westerlund, Hugo
Zins, Marie
Hamer, Mark
Batty, G. David
Kivimäki, Mika
author_sort Nyberg, Solja T.
collection PubMed
description IMPORTANCE: It is well established that selected lifestyle factors are individually associated with lower risk of chronic diseases, but how combinations of these factors are associated with disease-free life-years is unknown. OBJECTIVE: To estimate the association between healthy lifestyle and the number of disease-free life-years. DESIGN, SETTING, AND PARTICIPANTS: A prospective multicohort study, including 12 European studies as part of the Individual-Participant-Data Meta-analysis in Working Populations Consortium, was performed. Participants included 116 043 people free of major noncommunicable disease at baseline from August 7, 1991, to May 31, 2006. Data analysis was conducted from May 22, 2018, to January 21, 2020. EXPOSURES: Four baseline lifestyle factors (smoking, body mass index, physical activity, and alcohol consumption) were each allocated a score based on risk status: optimal (2 points), intermediate (1 point), or poor (0 points) resulting in an aggregated lifestyle score ranging from 0 (worst) to 8 (best). Sixteen lifestyle profiles were constructed from combinations of these risk factors. MAIN OUTCOMES AND MEASURES: The number of years between ages 40 and 75 years without chronic disease, including type 2 diabetes, coronary heart disease, stroke, cancer, asthma, and chronic obstructive pulmonary disease. RESULTS: Of the 116 043 people included in the analysis, the mean (SD) age was 43.7 (10.1) years and 70 911 were women (61.1%). During 1.45 million person-years at risk (mean follow-up, 12.5 years; range, 4.9-18.6 years), 17 383 participants developed at least 1 chronic disease. There was a linear association between overall healthy lifestyle score and the number of disease-free years, such that a 1-point improvement in the score was associated with an increase of 0.96 (95% CI, 0.83-1.08) disease-free years in men and 0.89 (95% CI, 0.75-1.02) years in women. Comparing the best lifestyle score with the worst lifestyle score was associated with 9.9 (95% CI 6.7-13.1) additional years without chronic diseases in men and 9.4 (95% CI 5.4-13.3) additional years in women (P < .001 for dose-response). All of the 4 lifestyle profiles that were associated with the highest number of disease-free years included a body-mass index less than 25 (calculated as weight in kilograms divided by height in meters squared) and at least 2 of the following factors: never smoking, physical activity, and moderate alcohol consumption. Participants with 1 of these lifestyle profiles reached age 70.3 (95% CI, 69.9-70.8) to 71.4 (95% CI, 70.9-72.0) years disease free depending on the profile and sex. CONCLUSIONS AND RELEVANCE: In this multicohort analysis, various healthy lifestyle profiles appeared to be associated with gains in life-years without major chronic diseases.
format Online
Article
Text
id pubmed-7136858
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher American Medical Association
record_format MEDLINE/PubMed
spelling pubmed-71368582020-04-08 Association of Healthy Lifestyle With Years Lived Without Major Chronic Diseases Nyberg, Solja T. Singh-Manoux, Archana Pentti, Jaana Madsen, Ida E. H. Sabia, Severine Alfredsson, Lars Bjorner, Jakob B. Borritz, Marianne Burr, Hermann Goldberg, Marcel Heikkilä, Katriina Jokela, Markus Knutsson, Anders Lallukka, Tea Lindbohm, Joni V. Nielsen, Martin L. Nordin, Maria Oksanen, Tuula Pejtersen, Jan H. Rahkonen, Ossi Rugulies, Reiner Shipley, Martin J. Sipilä, Pyry N. Stenholm, Sari Suominen, Sakari Vahtera, Jussi Virtanen, Marianna Westerlund, Hugo Zins, Marie Hamer, Mark Batty, G. David Kivimäki, Mika JAMA Intern Med Original Investigation IMPORTANCE: It is well established that selected lifestyle factors are individually associated with lower risk of chronic diseases, but how combinations of these factors are associated with disease-free life-years is unknown. OBJECTIVE: To estimate the association between healthy lifestyle and the number of disease-free life-years. DESIGN, SETTING, AND PARTICIPANTS: A prospective multicohort study, including 12 European studies as part of the Individual-Participant-Data Meta-analysis in Working Populations Consortium, was performed. Participants included 116 043 people free of major noncommunicable disease at baseline from August 7, 1991, to May 31, 2006. Data analysis was conducted from May 22, 2018, to January 21, 2020. EXPOSURES: Four baseline lifestyle factors (smoking, body mass index, physical activity, and alcohol consumption) were each allocated a score based on risk status: optimal (2 points), intermediate (1 point), or poor (0 points) resulting in an aggregated lifestyle score ranging from 0 (worst) to 8 (best). Sixteen lifestyle profiles were constructed from combinations of these risk factors. MAIN OUTCOMES AND MEASURES: The number of years between ages 40 and 75 years without chronic disease, including type 2 diabetes, coronary heart disease, stroke, cancer, asthma, and chronic obstructive pulmonary disease. RESULTS: Of the 116 043 people included in the analysis, the mean (SD) age was 43.7 (10.1) years and 70 911 were women (61.1%). During 1.45 million person-years at risk (mean follow-up, 12.5 years; range, 4.9-18.6 years), 17 383 participants developed at least 1 chronic disease. There was a linear association between overall healthy lifestyle score and the number of disease-free years, such that a 1-point improvement in the score was associated with an increase of 0.96 (95% CI, 0.83-1.08) disease-free years in men and 0.89 (95% CI, 0.75-1.02) years in women. Comparing the best lifestyle score with the worst lifestyle score was associated with 9.9 (95% CI 6.7-13.1) additional years without chronic diseases in men and 9.4 (95% CI 5.4-13.3) additional years in women (P < .001 for dose-response). All of the 4 lifestyle profiles that were associated with the highest number of disease-free years included a body-mass index less than 25 (calculated as weight in kilograms divided by height in meters squared) and at least 2 of the following factors: never smoking, physical activity, and moderate alcohol consumption. Participants with 1 of these lifestyle profiles reached age 70.3 (95% CI, 69.9-70.8) to 71.4 (95% CI, 70.9-72.0) years disease free depending on the profile and sex. CONCLUSIONS AND RELEVANCE: In this multicohort analysis, various healthy lifestyle profiles appeared to be associated with gains in life-years without major chronic diseases. American Medical Association 2020-05 2020-04-06 /pmc/articles/PMC7136858/ /pubmed/32250383 http://dx.doi.org/10.1001/jamainternmed.2020.0618 Text en Copyright 2020 Nyberg ST et al. JAMA Internal Medicine. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the CC-BY License.
spellingShingle Original Investigation
Nyberg, Solja T.
Singh-Manoux, Archana
Pentti, Jaana
Madsen, Ida E. H.
Sabia, Severine
Alfredsson, Lars
Bjorner, Jakob B.
Borritz, Marianne
Burr, Hermann
Goldberg, Marcel
Heikkilä, Katriina
Jokela, Markus
Knutsson, Anders
Lallukka, Tea
Lindbohm, Joni V.
Nielsen, Martin L.
Nordin, Maria
Oksanen, Tuula
Pejtersen, Jan H.
Rahkonen, Ossi
Rugulies, Reiner
Shipley, Martin J.
Sipilä, Pyry N.
Stenholm, Sari
Suominen, Sakari
Vahtera, Jussi
Virtanen, Marianna
Westerlund, Hugo
Zins, Marie
Hamer, Mark
Batty, G. David
Kivimäki, Mika
Association of Healthy Lifestyle With Years Lived Without Major Chronic Diseases
title Association of Healthy Lifestyle With Years Lived Without Major Chronic Diseases
title_full Association of Healthy Lifestyle With Years Lived Without Major Chronic Diseases
title_fullStr Association of Healthy Lifestyle With Years Lived Without Major Chronic Diseases
title_full_unstemmed Association of Healthy Lifestyle With Years Lived Without Major Chronic Diseases
title_short Association of Healthy Lifestyle With Years Lived Without Major Chronic Diseases
title_sort association of healthy lifestyle with years lived without major chronic diseases
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136858/
https://www.ncbi.nlm.nih.gov/pubmed/32250383
http://dx.doi.org/10.1001/jamainternmed.2020.0618
work_keys_str_mv AT nybergsoljat associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT singhmanouxarchana associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT penttijaana associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT madsenidaeh associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT sabiaseverine associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT alfredssonlars associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT bjornerjakobb associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT borritzmarianne associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT burrhermann associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT goldbergmarcel associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT heikkilakatriina associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT jokelamarkus associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT knutssonanders associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT lallukkatea associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT lindbohmjoniv associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT nielsenmartinl associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT nordinmaria associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT oksanentuula associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT pejtersenjanh associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT rahkonenossi associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT ruguliesreiner associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT shipleymartinj associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT sipilapyryn associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT stenholmsari associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT suominensakari associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT vahterajussi associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT virtanenmarianna associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT westerlundhugo associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT zinsmarie associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT hamermark associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT battygdavid associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases
AT kivimakimika associationofhealthylifestylewithyearslivedwithoutmajorchronicdiseases