Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells

The transcription factor ∆Np63 is a master regulator of epithelial cell identity and essential for the survival of squamous cell carcinoma (SCC) of lung, head and neck, oesophagus, cervix and skin. Here, we report that the deubiquitylase USP28 stabilizes ∆Np63 and maintains elevated ∆NP63 levels in...

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Detalles Bibliográficos
Autores principales: Prieto‐Garcia, Cristian, Hartmann, Oliver, Reissland, Michaela, Braun, Fabian, Fischer, Thomas, Walz, Susanne, Schülein‐Völk, Christina, Eilers, Ursula, Ade, Carsten P, Calzado, Marco A, Orian, Amir, Maric, Hans M, Münch, Christian, Rosenfeldt, Mathias, Eilers, Martin, Diefenbacher, Markus E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136964/
https://www.ncbi.nlm.nih.gov/pubmed/32128997
http://dx.doi.org/10.15252/emmm.201911101

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