A paracrine activin A–mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming

Cancer‐associated fibroblasts (CAFs) are key regulators of tumorigenesis and promising targets for next‐generation therapies. We discovered that cancer cell‐derived activin A reprograms fibroblasts into pro‐tumorigenic CAFs. Mechanistically, this occurs via Smad2‐mediated transcriptional regulation...

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Detalles Bibliográficos
Autores principales: Cangkrama, Michael, Wietecha, Mateusz, Mathis, Nicolas, Okumura, Rin, Ferrarese, Luca, Al‐Nuaimi, Dunja, Antsiferova, Maria, Dummer, Reinhard, Innocenti, Metello, Werner, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136968/
https://www.ncbi.nlm.nih.gov/pubmed/32150356
http://dx.doi.org/10.15252/emmm.201911466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136968/
https://www.ncbi.nlm.nih.gov/pubmed/32150356
http://dx.doi.org/10.15252/emmm.201911466

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