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Updates of colorectal cancer liver metastases therapy: review on DEBIRI

Colorectal cancer is a worldwide public health issue, presenting an advanced stage at diagnosis in more than 20% of patients. Liver metastases are the most common metastatic sites and are not indicated for resection in 80% of cases. Unresectable colorectal cancer liver metastases that are refractory...

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Autores principales: Fiorentini, Giammaria, Sarti, Donatella, Nani, Roberto, Aliberti, Camillo, Fiorentini, Caterina, Guadagni, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137176/
https://www.ncbi.nlm.nih.gov/pubmed/32273974
http://dx.doi.org/10.2217/hep-2019-0010
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author Fiorentini, Giammaria
Sarti, Donatella
Nani, Roberto
Aliberti, Camillo
Fiorentini, Caterina
Guadagni, Stefano
author_facet Fiorentini, Giammaria
Sarti, Donatella
Nani, Roberto
Aliberti, Camillo
Fiorentini, Caterina
Guadagni, Stefano
author_sort Fiorentini, Giammaria
collection PubMed
description Colorectal cancer is a worldwide public health issue, presenting an advanced stage at diagnosis in more than 20% of patients. Liver metastases are the most common metastatic sites and are not indicated for resection in 80% of cases. Unresectable colorectal cancer liver metastases that are refractory to systemic chemotherapy may benefit from transarterial chembolization with irinotecan-loaded beads (DEBIRI). Several studies show the safety and efficacy of DEBIRI for the treatment of colorectal cancer liver metastases. The development of transarterial chembolization and the introduction of new embolics have contributed to better outcomes of DEBIRI. This article reviews the current literature on DEBIRI reporting its use, efficacy in terms of tumor response and survival and side effects.
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spelling pubmed-71371762020-04-09 Updates of colorectal cancer liver metastases therapy: review on DEBIRI Fiorentini, Giammaria Sarti, Donatella Nani, Roberto Aliberti, Camillo Fiorentini, Caterina Guadagni, Stefano Hepat Oncol Review Colorectal cancer is a worldwide public health issue, presenting an advanced stage at diagnosis in more than 20% of patients. Liver metastases are the most common metastatic sites and are not indicated for resection in 80% of cases. Unresectable colorectal cancer liver metastases that are refractory to systemic chemotherapy may benefit from transarterial chembolization with irinotecan-loaded beads (DEBIRI). Several studies show the safety and efficacy of DEBIRI for the treatment of colorectal cancer liver metastases. The development of transarterial chembolization and the introduction of new embolics have contributed to better outcomes of DEBIRI. This article reviews the current literature on DEBIRI reporting its use, efficacy in terms of tumor response and survival and side effects. Future Medicine Ltd 2020-01-21 /pmc/articles/PMC7137176/ /pubmed/32273974 http://dx.doi.org/10.2217/hep-2019-0010 Text en © 2020 Giammaria Fiorentini This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Review
Fiorentini, Giammaria
Sarti, Donatella
Nani, Roberto
Aliberti, Camillo
Fiorentini, Caterina
Guadagni, Stefano
Updates of colorectal cancer liver metastases therapy: review on DEBIRI
title Updates of colorectal cancer liver metastases therapy: review on DEBIRI
title_full Updates of colorectal cancer liver metastases therapy: review on DEBIRI
title_fullStr Updates of colorectal cancer liver metastases therapy: review on DEBIRI
title_full_unstemmed Updates of colorectal cancer liver metastases therapy: review on DEBIRI
title_short Updates of colorectal cancer liver metastases therapy: review on DEBIRI
title_sort updates of colorectal cancer liver metastases therapy: review on debiri
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137176/
https://www.ncbi.nlm.nih.gov/pubmed/32273974
http://dx.doi.org/10.2217/hep-2019-0010
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