Optimal control strategy for the effects of hard water consumption on kidney-related diseases

OBJECTIVES : We study the optimal control strategy for the effects of hard water consumption on kidney-related diseases. The mathematical model has been formulated and studied to gain insights on the optimal control strategy on the effects of hard-water consumption on kidney-related diseases. The po...

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Detalles Bibliográficos
Autores principales: Ndii, Meksianis Z., Berkanis, Fransiska R., Tambaru, David, Lobo, Maria, Ariyanto, Djahi, Bertha S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137219/
https://www.ncbi.nlm.nih.gov/pubmed/32252815
http://dx.doi.org/10.1186/s13104-020-05043-z
Descripción
Sumario:OBJECTIVES : We study the optimal control strategy for the effects of hard water consumption on kidney-related diseases. The mathematical model has been formulated and studied to gain insights on the optimal control strategy on the effects of hard-water consumption on kidney-related diseases. The positivity and boundedness of the solutions are determined. A global sensitivity analysis has been performed and the numerical solutions have been carried out. RESULTS : A global sensitivity analysis shows that the control on water is an important parameter. This can reduce the proportion of individuals with kidney-dysfunction and hence reduces the proportion of individuals with kidney-related diseases. Furthermore, the numerical solutions show that with the optimal control, the proportion of individuals with kidney-related diseases can be minimised.

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