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Comparison of CTV(HR) and organs at risk contours between TRUS and MR images in IB cervical cancers: a proof of concept study
PURPOSE: To compare CTV(HR) and OAR dimensions and inter-rater agreement between magnetic resonance (MR) and trans-rectal ultrasound (TRUS) images in IB cervical cancer patients. METHODS: IB cervical cancer patients treated with (chemo)radiotherapy plus MR-guided brachytherapy (BT) were prospectivel...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137277/ https://www.ncbi.nlm.nih.gov/pubmed/32252792 http://dx.doi.org/10.1186/s13014-020-01516-4 |
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author | Mendez, Lucas C. Ravi, Ananth Martell, Kevin Raziee, Hamid Alayed, Yasir Wronski, Matt Paudel, Moti Barnes, Elizabeth Taggar, Amandeep Wong, C. S. Leung, Eric |
author_facet | Mendez, Lucas C. Ravi, Ananth Martell, Kevin Raziee, Hamid Alayed, Yasir Wronski, Matt Paudel, Moti Barnes, Elizabeth Taggar, Amandeep Wong, C. S. Leung, Eric |
author_sort | Mendez, Lucas C. |
collection | PubMed |
description | PURPOSE: To compare CTV(HR) and OAR dimensions and inter-rater agreement between magnetic resonance (MR) and trans-rectal ultrasound (TRUS) images in IB cervical cancer patients. METHODS: IB cervical cancer patients treated with (chemo)radiotherapy plus MR-guided brachytherapy (BT) were prospectively enrolled in this study. Radiation oncologists contoured CTV(HR) and OARs in pre-BT MR images (MRI) and intra-operative TRUS images. These contours were subsequently compared in regard to volume and dimension. Contour inter-rater agreement analysis was also investigated using kappa index (KI). Stata 15.0 was used for statistical analysis and a p-value < 0.05 was considered statistically significant. RESULTS: TRUS CTV(HR) volumes were statistically smaller than the respective MRI contoured volumes. TRUS CTV(HR) thickness was found to be consistently smaller than MRI contours in all patients. No statistical difference was seen in width and height between the two different imaging modalities. MRI contours had a median KI of 0.66 (range: 0.56–0.77) while TRUS-based contours had a median KI of 0.64 (range: 0.47–0.77). Bladder and rectum had very satisfactory KI in both imaging modalities. Vaginal contours had moderate agreement in MR (0.52) and in TRUS images (0.58). CONCLUSION: TRUS images allow good visualization of CTV(HR) and OARs in IB cervical cancer patients. Inter-rater contour variability was comparable between TRUS and MR images. TRUS is a promising modality on its own for image-guided BT. |
format | Online Article Text |
id | pubmed-7137277 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-71372772020-04-11 Comparison of CTV(HR) and organs at risk contours between TRUS and MR images in IB cervical cancers: a proof of concept study Mendez, Lucas C. Ravi, Ananth Martell, Kevin Raziee, Hamid Alayed, Yasir Wronski, Matt Paudel, Moti Barnes, Elizabeth Taggar, Amandeep Wong, C. S. Leung, Eric Radiat Oncol Research PURPOSE: To compare CTV(HR) and OAR dimensions and inter-rater agreement between magnetic resonance (MR) and trans-rectal ultrasound (TRUS) images in IB cervical cancer patients. METHODS: IB cervical cancer patients treated with (chemo)radiotherapy plus MR-guided brachytherapy (BT) were prospectively enrolled in this study. Radiation oncologists contoured CTV(HR) and OARs in pre-BT MR images (MRI) and intra-operative TRUS images. These contours were subsequently compared in regard to volume and dimension. Contour inter-rater agreement analysis was also investigated using kappa index (KI). Stata 15.0 was used for statistical analysis and a p-value < 0.05 was considered statistically significant. RESULTS: TRUS CTV(HR) volumes were statistically smaller than the respective MRI contoured volumes. TRUS CTV(HR) thickness was found to be consistently smaller than MRI contours in all patients. No statistical difference was seen in width and height between the two different imaging modalities. MRI contours had a median KI of 0.66 (range: 0.56–0.77) while TRUS-based contours had a median KI of 0.64 (range: 0.47–0.77). Bladder and rectum had very satisfactory KI in both imaging modalities. Vaginal contours had moderate agreement in MR (0.52) and in TRUS images (0.58). CONCLUSION: TRUS images allow good visualization of CTV(HR) and OARs in IB cervical cancer patients. Inter-rater contour variability was comparable between TRUS and MR images. TRUS is a promising modality on its own for image-guided BT. BioMed Central 2020-04-06 /pmc/articles/PMC7137277/ /pubmed/32252792 http://dx.doi.org/10.1186/s13014-020-01516-4 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Mendez, Lucas C. Ravi, Ananth Martell, Kevin Raziee, Hamid Alayed, Yasir Wronski, Matt Paudel, Moti Barnes, Elizabeth Taggar, Amandeep Wong, C. S. Leung, Eric Comparison of CTV(HR) and organs at risk contours between TRUS and MR images in IB cervical cancers: a proof of concept study |
title | Comparison of CTV(HR) and organs at risk contours between TRUS and MR images in IB cervical cancers: a proof of concept study |
title_full | Comparison of CTV(HR) and organs at risk contours between TRUS and MR images in IB cervical cancers: a proof of concept study |
title_fullStr | Comparison of CTV(HR) and organs at risk contours between TRUS and MR images in IB cervical cancers: a proof of concept study |
title_full_unstemmed | Comparison of CTV(HR) and organs at risk contours between TRUS and MR images in IB cervical cancers: a proof of concept study |
title_short | Comparison of CTV(HR) and organs at risk contours between TRUS and MR images in IB cervical cancers: a proof of concept study |
title_sort | comparison of ctv(hr) and organs at risk contours between trus and mr images in ib cervical cancers: a proof of concept study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137277/ https://www.ncbi.nlm.nih.gov/pubmed/32252792 http://dx.doi.org/10.1186/s13014-020-01516-4 |
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