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Disrupting the LC3 Interaction Region (LIR) Binding of Selective Autophagy Receptors Sensitizes AML Cell Lines to Cytarabine

Short linear motifs (SLiMs) located in disordered regions of multidomain proteins are important for the organization of protein–protein interaction networks. By dynamic association with their binding partners, SLiMs enable assembly of multiprotein complexes, pivotal for the regulation of various asp...

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Detalles Bibliográficos
Autores principales: Putyrski, Mateusz, Vakhrusheva, Olesya, Bonn, Florian, Guntur, Suchithra, Vorobyov, Andrew, Brandts, Christian, Dikic, Ivan, Ernst, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137635/
https://www.ncbi.nlm.nih.gov/pubmed/32296703
http://dx.doi.org/10.3389/fcell.2020.00208