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Association between Parvovirus B19 and anemia in HIV-infected patients
Background: Human parvovirus B19 (B19V) can cause anemia in some patients, including those with compromised immunity system. There are a few studies on molecular epidemiology of B19V and its association with anemia in Iran. Therefore, the aim of this study was to determine the B19V DNA, IgM, IgG, ge...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iran University of Medical Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137816/ https://www.ncbi.nlm.nih.gov/pubmed/32280643 http://dx.doi.org/10.34171/mjiri.33.137 |
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author | Nouri, Majid Kamakifar, Parvin Khodabandehlou, Niloofar Sadri Nahand, Javid Tavakoli, Ahmad Norooznezhad, Fatemeh Sorayyayi, Saba Babaei, Farhad Mostafaei, Shayan Moghoofei, Mohsen |
author_facet | Nouri, Majid Kamakifar, Parvin Khodabandehlou, Niloofar Sadri Nahand, Javid Tavakoli, Ahmad Norooznezhad, Fatemeh Sorayyayi, Saba Babaei, Farhad Mostafaei, Shayan Moghoofei, Mohsen |
author_sort | Nouri, Majid |
collection | PubMed |
description | Background: Human parvovirus B19 (B19V) can cause anemia in some patients, including those with compromised immunity system. There are a few studies on molecular epidemiology of B19V and its association with anemia in Iran. Therefore, the aim of this study was to determine the B19V DNA, IgM, IgG, genotyping, and viral load in HIV patients in different groups of pregnant women, general population, injection drug users (IDU), and Elite controllers. Also, the possible association of B19V with anemia was studied. Methods: In this case-control study, B19V DNA, anti-B19V IgM, anti-B19V IgG, viral load, and hemoglobin level were assessed in 113 HIV positive patients and 72 healthy controls. Also, CD4+ T cell counts and HIV load were measured in the patients’ group. All statistical analyses were done using STATA 14.2 software (Stata Corporation, College Station, Texas, USA). P value < 0.05 was considered statistically significant. Results: Among HIV patients, 19 (16.8%) cases had B19V DNA, 3 (2.7%) had B19V IgM, and 7 (6.2%) had B19V IgG. In control group, the prevalence of B19V DNA, IgM, and IgG was 6 (8.33%), 7(9.7%), and 19 (26.4%), respectively. In subpopulations based on transmission routes, general population had the highest B19V IgG and DNA positivity prevalence and viral load level. There was no significant association between B19V antibodies and DNA with anemia. Conclusion: The results demonstrated that B19V infection cannot be considered as a high-risk factor for anemia in adult HIV patients. However, further studies are needed to determine the exact role of B19V infection in HIV patients. |
format | Online Article Text |
id | pubmed-7137816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Iran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-71378162020-04-10 Association between Parvovirus B19 and anemia in HIV-infected patients Nouri, Majid Kamakifar, Parvin Khodabandehlou, Niloofar Sadri Nahand, Javid Tavakoli, Ahmad Norooznezhad, Fatemeh Sorayyayi, Saba Babaei, Farhad Mostafaei, Shayan Moghoofei, Mohsen Med J Islam Repub Iran Original Article Background: Human parvovirus B19 (B19V) can cause anemia in some patients, including those with compromised immunity system. There are a few studies on molecular epidemiology of B19V and its association with anemia in Iran. Therefore, the aim of this study was to determine the B19V DNA, IgM, IgG, genotyping, and viral load in HIV patients in different groups of pregnant women, general population, injection drug users (IDU), and Elite controllers. Also, the possible association of B19V with anemia was studied. Methods: In this case-control study, B19V DNA, anti-B19V IgM, anti-B19V IgG, viral load, and hemoglobin level were assessed in 113 HIV positive patients and 72 healthy controls. Also, CD4+ T cell counts and HIV load were measured in the patients’ group. All statistical analyses were done using STATA 14.2 software (Stata Corporation, College Station, Texas, USA). P value < 0.05 was considered statistically significant. Results: Among HIV patients, 19 (16.8%) cases had B19V DNA, 3 (2.7%) had B19V IgM, and 7 (6.2%) had B19V IgG. In control group, the prevalence of B19V DNA, IgM, and IgG was 6 (8.33%), 7(9.7%), and 19 (26.4%), respectively. In subpopulations based on transmission routes, general population had the highest B19V IgG and DNA positivity prevalence and viral load level. There was no significant association between B19V antibodies and DNA with anemia. Conclusion: The results demonstrated that B19V infection cannot be considered as a high-risk factor for anemia in adult HIV patients. However, further studies are needed to determine the exact role of B19V infection in HIV patients. Iran University of Medical Sciences 2019-12-16 /pmc/articles/PMC7137816/ /pubmed/32280643 http://dx.doi.org/10.34171/mjiri.33.137 Text en © 2019 Iran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Original Article Nouri, Majid Kamakifar, Parvin Khodabandehlou, Niloofar Sadri Nahand, Javid Tavakoli, Ahmad Norooznezhad, Fatemeh Sorayyayi, Saba Babaei, Farhad Mostafaei, Shayan Moghoofei, Mohsen Association between Parvovirus B19 and anemia in HIV-infected patients |
title | Association between Parvovirus B19 and anemia in HIV-infected patients |
title_full | Association between Parvovirus B19 and anemia in HIV-infected patients |
title_fullStr | Association between Parvovirus B19 and anemia in HIV-infected patients |
title_full_unstemmed | Association between Parvovirus B19 and anemia in HIV-infected patients |
title_short | Association between Parvovirus B19 and anemia in HIV-infected patients |
title_sort | association between parvovirus b19 and anemia in hiv-infected patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137816/ https://www.ncbi.nlm.nih.gov/pubmed/32280643 http://dx.doi.org/10.34171/mjiri.33.137 |
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