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Oncogene inference optimization using constraint-based modelling incorporated with protein expression in normal and tumour tissues

Cancer cells are known to exhibit unusual metabolic activity, and yet few metabolic cancer driver genes are known. Genetic alterations and epigenetic modifications of cancer cells result in the abnormal regulation of cellular metabolic pathways that are different when compared with normal cells. Suc...

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Detalles Bibliográficos
Autores principales: Wu, Wu-Hsiung, Li, Fan-Yu, Shu, Yi-Chen, Lai, Jin-Mei, Chang, Peter Mu-Hsin, Huang, Chi-Ying F., Wang, Feng-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137941/
https://www.ncbi.nlm.nih.gov/pubmed/32269785
http://dx.doi.org/10.1098/rsos.191241