Cargando…
The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma
It is increasingly evident that non-coding RNAs play a significant role in tumour development. However, we still have a limited knowledge of the clinical significance of long non-coding RNAs (lncRNAs) in lung cancer. The FENDRR is a long coding RNA (also named FOXF1-AS1) located in the vicinity of t...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138163/ https://www.ncbi.nlm.nih.gov/pubmed/32284793 |
_version_ | 1783518543111782400 |
---|---|
author | Herrera-Merchan, Antonio Cuadros, Marta Rodriguez, Maria Isabel Rodriguez, Sandra Torres, Raul Estecio, Marcos Coira, Isabel F. Loidi, Claudia Saiz, Monica Carmona-Saez, Pedro Medina, Pedro P. |
author_facet | Herrera-Merchan, Antonio Cuadros, Marta Rodriguez, Maria Isabel Rodriguez, Sandra Torres, Raul Estecio, Marcos Coira, Isabel F. Loidi, Claudia Saiz, Monica Carmona-Saez, Pedro Medina, Pedro P. |
author_sort | Herrera-Merchan, Antonio |
collection | PubMed |
description | It is increasingly evident that non-coding RNAs play a significant role in tumour development. However, we still have a limited knowledge of the clinical significance of long non-coding RNAs (lncRNAs) in lung cancer. The FENDRR is a long coding RNA (also named FOXF1-AS1) located in the vicinity of the protein-coding gene FOXF1 at 16q24.1 chromosomal region. The present study aimed to define the clinic pathological significance of the long-non-coding RNA FENDRR in lung adenocarcinomas. FENDRR expression measured by quantitative PCR was found significantly downregulated (p<0.001) in lung adenocarcinoma samples in comparison with their normal adjacent tissues (n=70). RNA in situ hybridization (RNA-FISH) corroborated independently the down-regulation of FENDRR. Interestingly, the expression of FENDRR correlated positively (p<0.001) with the expression of its protein-coding neighbor gene FOXF1. Additionally, FOXF1 expression was also found downregulated in adenocarcinomas compared to normal samples (p<0.001) and its expression was significantly correlated with overall survival alone (p=0.003) or in combination with FENDRR expression (p=0.01). In conclusion, our data support that FENDRR and FOXF1 expression is decreased in lung adenocarcinoma and should be considered as new potential diagnostic/prognosis biomarkers. |
format | Online Article Text |
id | pubmed-7138163 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-71381632020-04-13 The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma Herrera-Merchan, Antonio Cuadros, Marta Rodriguez, Maria Isabel Rodriguez, Sandra Torres, Raul Estecio, Marcos Coira, Isabel F. Loidi, Claudia Saiz, Monica Carmona-Saez, Pedro Medina, Pedro P. Oncotarget Research Paper It is increasingly evident that non-coding RNAs play a significant role in tumour development. However, we still have a limited knowledge of the clinical significance of long non-coding RNAs (lncRNAs) in lung cancer. The FENDRR is a long coding RNA (also named FOXF1-AS1) located in the vicinity of the protein-coding gene FOXF1 at 16q24.1 chromosomal region. The present study aimed to define the clinic pathological significance of the long-non-coding RNA FENDRR in lung adenocarcinomas. FENDRR expression measured by quantitative PCR was found significantly downregulated (p<0.001) in lung adenocarcinoma samples in comparison with their normal adjacent tissues (n=70). RNA in situ hybridization (RNA-FISH) corroborated independently the down-regulation of FENDRR. Interestingly, the expression of FENDRR correlated positively (p<0.001) with the expression of its protein-coding neighbor gene FOXF1. Additionally, FOXF1 expression was also found downregulated in adenocarcinomas compared to normal samples (p<0.001) and its expression was significantly correlated with overall survival alone (p=0.003) or in combination with FENDRR expression (p=0.01). In conclusion, our data support that FENDRR and FOXF1 expression is decreased in lung adenocarcinoma and should be considered as new potential diagnostic/prognosis biomarkers. Impact Journals LLC 2017-10-27 /pmc/articles/PMC7138163/ /pubmed/32284793 Text en Copyright: © 2017 Herrera-Merchan et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Herrera-Merchan, Antonio Cuadros, Marta Rodriguez, Maria Isabel Rodriguez, Sandra Torres, Raul Estecio, Marcos Coira, Isabel F. Loidi, Claudia Saiz, Monica Carmona-Saez, Pedro Medina, Pedro P. The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma |
title | The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma |
title_full | The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma |
title_fullStr | The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma |
title_full_unstemmed | The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma |
title_short | The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma |
title_sort | value of lncrna fendrr and foxf1 as a prognostic factor for survival of lung adenocarcinoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138163/ https://www.ncbi.nlm.nih.gov/pubmed/32284793 |
work_keys_str_mv | AT herreramerchanantonio thevalueoflncrnafendrrandfoxf1asaprognosticfactorforsurvivaloflungadenocarcinoma AT cuadrosmarta thevalueoflncrnafendrrandfoxf1asaprognosticfactorforsurvivaloflungadenocarcinoma AT rodriguezmariaisabel thevalueoflncrnafendrrandfoxf1asaprognosticfactorforsurvivaloflungadenocarcinoma AT rodriguezsandra thevalueoflncrnafendrrandfoxf1asaprognosticfactorforsurvivaloflungadenocarcinoma AT torresraul thevalueoflncrnafendrrandfoxf1asaprognosticfactorforsurvivaloflungadenocarcinoma AT esteciomarcos thevalueoflncrnafendrrandfoxf1asaprognosticfactorforsurvivaloflungadenocarcinoma AT coiraisabelf thevalueoflncrnafendrrandfoxf1asaprognosticfactorforsurvivaloflungadenocarcinoma AT loidiclaudia thevalueoflncrnafendrrandfoxf1asaprognosticfactorforsurvivaloflungadenocarcinoma AT saizmonica thevalueoflncrnafendrrandfoxf1asaprognosticfactorforsurvivaloflungadenocarcinoma AT carmonasaezpedro thevalueoflncrnafendrrandfoxf1asaprognosticfactorforsurvivaloflungadenocarcinoma AT medinapedrop thevalueoflncrnafendrrandfoxf1asaprognosticfactorforsurvivaloflungadenocarcinoma AT herreramerchanantonio valueoflncrnafendrrandfoxf1asaprognosticfactorforsurvivaloflungadenocarcinoma AT cuadrosmarta valueoflncrnafendrrandfoxf1asaprognosticfactorforsurvivaloflungadenocarcinoma AT rodriguezmariaisabel valueoflncrnafendrrandfoxf1asaprognosticfactorforsurvivaloflungadenocarcinoma AT rodriguezsandra valueoflncrnafendrrandfoxf1asaprognosticfactorforsurvivaloflungadenocarcinoma AT torresraul valueoflncrnafendrrandfoxf1asaprognosticfactorforsurvivaloflungadenocarcinoma AT esteciomarcos valueoflncrnafendrrandfoxf1asaprognosticfactorforsurvivaloflungadenocarcinoma AT coiraisabelf valueoflncrnafendrrandfoxf1asaprognosticfactorforsurvivaloflungadenocarcinoma AT loidiclaudia valueoflncrnafendrrandfoxf1asaprognosticfactorforsurvivaloflungadenocarcinoma AT saizmonica valueoflncrnafendrrandfoxf1asaprognosticfactorforsurvivaloflungadenocarcinoma AT carmonasaezpedro valueoflncrnafendrrandfoxf1asaprognosticfactorforsurvivaloflungadenocarcinoma AT medinapedrop valueoflncrnafendrrandfoxf1asaprognosticfactorforsurvivaloflungadenocarcinoma |