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The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma

It is increasingly evident that non-coding RNAs play a significant role in tumour development. However, we still have a limited knowledge of the clinical significance of long non-coding RNAs (lncRNAs) in lung cancer. The FENDRR is a long coding RNA (also named FOXF1-AS1) located in the vicinity of t...

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Autores principales: Herrera-Merchan, Antonio, Cuadros, Marta, Rodriguez, Maria Isabel, Rodriguez, Sandra, Torres, Raul, Estecio, Marcos, Coira, Isabel F., Loidi, Claudia, Saiz, Monica, Carmona-Saez, Pedro, Medina, Pedro P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138163/
https://www.ncbi.nlm.nih.gov/pubmed/32284793
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author Herrera-Merchan, Antonio
Cuadros, Marta
Rodriguez, Maria Isabel
Rodriguez, Sandra
Torres, Raul
Estecio, Marcos
Coira, Isabel F.
Loidi, Claudia
Saiz, Monica
Carmona-Saez, Pedro
Medina, Pedro P.
author_facet Herrera-Merchan, Antonio
Cuadros, Marta
Rodriguez, Maria Isabel
Rodriguez, Sandra
Torres, Raul
Estecio, Marcos
Coira, Isabel F.
Loidi, Claudia
Saiz, Monica
Carmona-Saez, Pedro
Medina, Pedro P.
author_sort Herrera-Merchan, Antonio
collection PubMed
description It is increasingly evident that non-coding RNAs play a significant role in tumour development. However, we still have a limited knowledge of the clinical significance of long non-coding RNAs (lncRNAs) in lung cancer. The FENDRR is a long coding RNA (also named FOXF1-AS1) located in the vicinity of the protein-coding gene FOXF1 at 16q24.1 chromosomal region. The present study aimed to define the clinic pathological significance of the long-non-coding RNA FENDRR in lung adenocarcinomas. FENDRR expression measured by quantitative PCR was found significantly downregulated (p<0.001) in lung adenocarcinoma samples in comparison with their normal adjacent tissues (n=70). RNA in situ hybridization (RNA-FISH) corroborated independently the down-regulation of FENDRR. Interestingly, the expression of FENDRR correlated positively (p<0.001) with the expression of its protein-coding neighbor gene FOXF1. Additionally, FOXF1 expression was also found downregulated in adenocarcinomas compared to normal samples (p<0.001) and its expression was significantly correlated with overall survival alone (p=0.003) or in combination with FENDRR expression (p=0.01). In conclusion, our data support that FENDRR and FOXF1 expression is decreased in lung adenocarcinoma and should be considered as new potential diagnostic/prognosis biomarkers.
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spelling pubmed-71381632020-04-13 The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma Herrera-Merchan, Antonio Cuadros, Marta Rodriguez, Maria Isabel Rodriguez, Sandra Torres, Raul Estecio, Marcos Coira, Isabel F. Loidi, Claudia Saiz, Monica Carmona-Saez, Pedro Medina, Pedro P. Oncotarget Research Paper It is increasingly evident that non-coding RNAs play a significant role in tumour development. However, we still have a limited knowledge of the clinical significance of long non-coding RNAs (lncRNAs) in lung cancer. The FENDRR is a long coding RNA (also named FOXF1-AS1) located in the vicinity of the protein-coding gene FOXF1 at 16q24.1 chromosomal region. The present study aimed to define the clinic pathological significance of the long-non-coding RNA FENDRR in lung adenocarcinomas. FENDRR expression measured by quantitative PCR was found significantly downregulated (p<0.001) in lung adenocarcinoma samples in comparison with their normal adjacent tissues (n=70). RNA in situ hybridization (RNA-FISH) corroborated independently the down-regulation of FENDRR. Interestingly, the expression of FENDRR correlated positively (p<0.001) with the expression of its protein-coding neighbor gene FOXF1. Additionally, FOXF1 expression was also found downregulated in adenocarcinomas compared to normal samples (p<0.001) and its expression was significantly correlated with overall survival alone (p=0.003) or in combination with FENDRR expression (p=0.01). In conclusion, our data support that FENDRR and FOXF1 expression is decreased in lung adenocarcinoma and should be considered as new potential diagnostic/prognosis biomarkers. Impact Journals LLC 2017-10-27 /pmc/articles/PMC7138163/ /pubmed/32284793 Text en Copyright: © 2017 Herrera-Merchan et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Herrera-Merchan, Antonio
Cuadros, Marta
Rodriguez, Maria Isabel
Rodriguez, Sandra
Torres, Raul
Estecio, Marcos
Coira, Isabel F.
Loidi, Claudia
Saiz, Monica
Carmona-Saez, Pedro
Medina, Pedro P.
The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma
title The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma
title_full The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma
title_fullStr The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma
title_full_unstemmed The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma
title_short The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma
title_sort value of lncrna fendrr and foxf1 as a prognostic factor for survival of lung adenocarcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138163/
https://www.ncbi.nlm.nih.gov/pubmed/32284793
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