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Role of thrombospondin-1 and thrombospondin-2 in cardiovascular diseases (Review)

Thrombospondin (TSP)-1 and TSP-2 are matricellular proteins in the extracellular matrix (ECM), which serve a significant role in the pathological processes of various cardiovascular diseases (CVDs). The multiple effects of TSP-1 and TSP-2 are due to their ability to interact with various ligands, su...

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Autores principales: Zhang, Kaijie, Li, Miaomiao, Yin, Li, Fu, Guosheng, Liu, Zhenjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138268/
https://www.ncbi.nlm.nih.gov/pubmed/32323748
http://dx.doi.org/10.3892/ijmm.2020.4507
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author Zhang, Kaijie
Li, Miaomiao
Yin, Li
Fu, Guosheng
Liu, Zhenjie
author_facet Zhang, Kaijie
Li, Miaomiao
Yin, Li
Fu, Guosheng
Liu, Zhenjie
author_sort Zhang, Kaijie
collection PubMed
description Thrombospondin (TSP)-1 and TSP-2 are matricellular proteins in the extracellular matrix (ECM), which serve a significant role in the pathological processes of various cardiovascular diseases (CVDs). The multiple effects of TSP-1 and TSP-2 are due to their ability to interact with various ligands, such as structural components of the ECM, cytokines, cellular receptors, growth factors, proteases and other stromal cell proteins. TSP-1 and TSP-2 regulate the structure and activity of the aforementioned ligands by interacting directly or indirectly with them, thereby regulating the activity of different types of cells in response to environmental stimuli. The pathological processes of numerous CVDs are associated with the degradation and remodeling of ECM components, and with cell migration, dysfunction and apoptosis, which may be regulated by TSP-1 and TSP-2 through different mechanisms. Therefore, investigating the role of TSP-1 and TSP-2 in different CVDs and the potential signaling pathways they are associated with may provide a new perspective on potential therapies for the treatment of CVDs. In the present review, the current understanding of the roles TSP-1 and TSP-2 serve in various CVDs were summarized. In addition, the interacting ligands and the potential pathways associated with these thrombospondins in CVDs are also discussed.
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spelling pubmed-71382682020-04-08 Role of thrombospondin-1 and thrombospondin-2 in cardiovascular diseases (Review) Zhang, Kaijie Li, Miaomiao Yin, Li Fu, Guosheng Liu, Zhenjie Int J Mol Med Articles Thrombospondin (TSP)-1 and TSP-2 are matricellular proteins in the extracellular matrix (ECM), which serve a significant role in the pathological processes of various cardiovascular diseases (CVDs). The multiple effects of TSP-1 and TSP-2 are due to their ability to interact with various ligands, such as structural components of the ECM, cytokines, cellular receptors, growth factors, proteases and other stromal cell proteins. TSP-1 and TSP-2 regulate the structure and activity of the aforementioned ligands by interacting directly or indirectly with them, thereby regulating the activity of different types of cells in response to environmental stimuli. The pathological processes of numerous CVDs are associated with the degradation and remodeling of ECM components, and with cell migration, dysfunction and apoptosis, which may be regulated by TSP-1 and TSP-2 through different mechanisms. Therefore, investigating the role of TSP-1 and TSP-2 in different CVDs and the potential signaling pathways they are associated with may provide a new perspective on potential therapies for the treatment of CVDs. In the present review, the current understanding of the roles TSP-1 and TSP-2 serve in various CVDs were summarized. In addition, the interacting ligands and the potential pathways associated with these thrombospondins in CVDs are also discussed. D.A. Spandidos 2020-05 2020-02-20 /pmc/articles/PMC7138268/ /pubmed/32323748 http://dx.doi.org/10.3892/ijmm.2020.4507 Text en Copyright: © Zhang et al. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License.
spellingShingle Articles
Zhang, Kaijie
Li, Miaomiao
Yin, Li
Fu, Guosheng
Liu, Zhenjie
Role of thrombospondin-1 and thrombospondin-2 in cardiovascular diseases (Review)
title Role of thrombospondin-1 and thrombospondin-2 in cardiovascular diseases (Review)
title_full Role of thrombospondin-1 and thrombospondin-2 in cardiovascular diseases (Review)
title_fullStr Role of thrombospondin-1 and thrombospondin-2 in cardiovascular diseases (Review)
title_full_unstemmed Role of thrombospondin-1 and thrombospondin-2 in cardiovascular diseases (Review)
title_short Role of thrombospondin-1 and thrombospondin-2 in cardiovascular diseases (Review)
title_sort role of thrombospondin-1 and thrombospondin-2 in cardiovascular diseases (review)
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138268/
https://www.ncbi.nlm.nih.gov/pubmed/32323748
http://dx.doi.org/10.3892/ijmm.2020.4507
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