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Aspirin inhibits endometrial fibrosis by suppressing the TGF-β1-Smad2/Smad3 pathway in intrauterine adhesions

Intrauterine adhesions (IUAs) represent one of the most common diseases in women of reproductive age. Patients with moderate-to-severe IUA can experience a decrease in normal menstrual patterns, amenorrhea and even infertility. At present, the first-line treatment strategies for IUAs in the clinical...

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Autores principales: Zhang, Zihui, Li, Shuang, Deng, Jie, Yang, Shaorong, Xiang, Ziwu, Guo, Hongyan, Xi, Hongli, Sang, Ming, Zhang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138280/
https://www.ncbi.nlm.nih.gov/pubmed/32323728
http://dx.doi.org/10.3892/ijmm.2020.4506
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author Zhang, Zihui
Li, Shuang
Deng, Jie
Yang, Shaorong
Xiang, Ziwu
Guo, Hongyan
Xi, Hongli
Sang, Ming
Zhang, Wei
author_facet Zhang, Zihui
Li, Shuang
Deng, Jie
Yang, Shaorong
Xiang, Ziwu
Guo, Hongyan
Xi, Hongli
Sang, Ming
Zhang, Wei
author_sort Zhang, Zihui
collection PubMed
description Intrauterine adhesions (IUAs) represent one of the most common diseases in women of reproductive age. Patients with moderate-to-severe IUA can experience a decrease in normal menstrual patterns, amenorrhea and even infertility. At present, the first-line treatment strategies for IUAs in the clinical practice are hysteroscopic transuterine resection of adhesion and postoperative adjuvant therapy, including oestrogen. However, a high recurrence rate of IUAs remains. In recent years, studies have demonstrated that aspirin combined with oestrogen may significantly prevent the postoperative disease recurrence rate, improve endometrial receptivity and improve the conception rate by increasing endometrial blood supply and angiogenesis more effectively. The TGF-β1-Smad2/Smad3 pathway is one of the important mechanisms involved in endometrial fibrosis. However, whether aspirin can inhibit endometrial fibrosis through the TGF-β1-Smad2/Smad3 pathway to prevent postoperative re-adhesion remains to be elucidated. The results of the present study suggested that aspirin inhibits endometrial fibrosis by suppressing the TGF-β1-Smad2/Smad3 pathway, which may provide new hypotheses for the mechanism of action of aspirin in the treatment of IUAs.
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spelling pubmed-71382802020-04-08 Aspirin inhibits endometrial fibrosis by suppressing the TGF-β1-Smad2/Smad3 pathway in intrauterine adhesions Zhang, Zihui Li, Shuang Deng, Jie Yang, Shaorong Xiang, Ziwu Guo, Hongyan Xi, Hongli Sang, Ming Zhang, Wei Int J Mol Med Articles Intrauterine adhesions (IUAs) represent one of the most common diseases in women of reproductive age. Patients with moderate-to-severe IUA can experience a decrease in normal menstrual patterns, amenorrhea and even infertility. At present, the first-line treatment strategies for IUAs in the clinical practice are hysteroscopic transuterine resection of adhesion and postoperative adjuvant therapy, including oestrogen. However, a high recurrence rate of IUAs remains. In recent years, studies have demonstrated that aspirin combined with oestrogen may significantly prevent the postoperative disease recurrence rate, improve endometrial receptivity and improve the conception rate by increasing endometrial blood supply and angiogenesis more effectively. The TGF-β1-Smad2/Smad3 pathway is one of the important mechanisms involved in endometrial fibrosis. However, whether aspirin can inhibit endometrial fibrosis through the TGF-β1-Smad2/Smad3 pathway to prevent postoperative re-adhesion remains to be elucidated. The results of the present study suggested that aspirin inhibits endometrial fibrosis by suppressing the TGF-β1-Smad2/Smad3 pathway, which may provide new hypotheses for the mechanism of action of aspirin in the treatment of IUAs. D.A. Spandidos 2020-05 2020-02-19 /pmc/articles/PMC7138280/ /pubmed/32323728 http://dx.doi.org/10.3892/ijmm.2020.4506 Text en Copyright: © Zhang et al. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License.
spellingShingle Articles
Zhang, Zihui
Li, Shuang
Deng, Jie
Yang, Shaorong
Xiang, Ziwu
Guo, Hongyan
Xi, Hongli
Sang, Ming
Zhang, Wei
Aspirin inhibits endometrial fibrosis by suppressing the TGF-β1-Smad2/Smad3 pathway in intrauterine adhesions
title Aspirin inhibits endometrial fibrosis by suppressing the TGF-β1-Smad2/Smad3 pathway in intrauterine adhesions
title_full Aspirin inhibits endometrial fibrosis by suppressing the TGF-β1-Smad2/Smad3 pathway in intrauterine adhesions
title_fullStr Aspirin inhibits endometrial fibrosis by suppressing the TGF-β1-Smad2/Smad3 pathway in intrauterine adhesions
title_full_unstemmed Aspirin inhibits endometrial fibrosis by suppressing the TGF-β1-Smad2/Smad3 pathway in intrauterine adhesions
title_short Aspirin inhibits endometrial fibrosis by suppressing the TGF-β1-Smad2/Smad3 pathway in intrauterine adhesions
title_sort aspirin inhibits endometrial fibrosis by suppressing the tgf-β1-smad2/smad3 pathway in intrauterine adhesions
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138280/
https://www.ncbi.nlm.nih.gov/pubmed/32323728
http://dx.doi.org/10.3892/ijmm.2020.4506
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