ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging

NF-κB is a transcription factor activated in response to inflammatory, genotoxic and oxidative stress and important for driving senescence and aging. Ataxia-telangiectasia mutated (ATM) kinase, a core component of DNA damage response signaling, activates NF-κB in response to genotoxic and oxidative...

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Detalles Bibliográficos
Autores principales: Zhao, Jing, Zhang, Lei, Lu, Aiping, Han, Yingchao, Colangelo, Debora, Bukata, Christina, Scibetta, Alex, Yousefzadeh, Matthew J., Li, Xuesen, Gurkar, Aditi U., McGowan, Sara J., Angelini, Luise, O’Kelly, Ryan, Li, Hongshuai, Corbo, Lana, Sano, Tokio, Nick, Heather, Pola, Enrico, Pilla, Smitha P.S., Ladiges, Warren C., Vo, Nam, Huard, Johnny, Niedernhofer, Laura J., Robbins, Paul D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138542/
https://www.ncbi.nlm.nih.gov/pubmed/32201398
http://dx.doi.org/10.18632/aging.102863

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