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Perspectives of Homo sapiens lifespan extension: focus on external or internal resources?
Homo sapiens and naked mole rats (Heterocephalus glaber) are vivid examples of social mammals that differ from their relatives in particular by an increased lifespan and a large number of neotenic features. An important fact for biogerontology is that the mortality rate of H. glaber (a maximal lifes...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138562/ https://www.ncbi.nlm.nih.gov/pubmed/32229707 http://dx.doi.org/10.18632/aging.102981 |
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author | Skulachev, Vladimir P. Shilovsky, Gregory A. Putyatina, Tatyana S. Popov, Nikita A. Markov, Alexander V. Skulachev, Maxim V. Sadovnichii, Victor A. |
author_facet | Skulachev, Vladimir P. Shilovsky, Gregory A. Putyatina, Tatyana S. Popov, Nikita A. Markov, Alexander V. Skulachev, Maxim V. Sadovnichii, Victor A. |
author_sort | Skulachev, Vladimir P. |
collection | PubMed |
description | Homo sapiens and naked mole rats (Heterocephalus glaber) are vivid examples of social mammals that differ from their relatives in particular by an increased lifespan and a large number of neotenic features. An important fact for biogerontology is that the mortality rate of H. glaber (a maximal lifespan of more than 32 years, which is very large for such a small rodent) negligibly grows with age. The same is true for modern people in developed countries below the age of 60. It is important that the juvenilization of traits that separate humans from chimpanzees evolved over thousands of generations and millions of years. Rapid advances in technology resulted in a sharp increase in the life expectancy of human beings during the past 100 years. Currently, the human life expectancy has exceeded 80 years in developed countries. It cannot be excluded that the potential for increasing life expectancy by an improvement in living conditions will be exhausted after a certain period of time. New types of geroprotectors should be developed that protect not only from chronic phenoptosis gradual poisoning of the body with reactive oxygen species (ROS) but also from acute phenoptosis, where strong increase in the level of ROS immediately kills an already aged individual. Geroprotectors might be another anti-aging strategy along with neoteny (a natural physiological phenomenon) and technical progress. |
format | Online Article Text |
id | pubmed-7138562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-71385622020-04-13 Perspectives of Homo sapiens lifespan extension: focus on external or internal resources? Skulachev, Vladimir P. Shilovsky, Gregory A. Putyatina, Tatyana S. Popov, Nikita A. Markov, Alexander V. Skulachev, Maxim V. Sadovnichii, Victor A. Aging (Albany NY) Research Perspective Homo sapiens and naked mole rats (Heterocephalus glaber) are vivid examples of social mammals that differ from their relatives in particular by an increased lifespan and a large number of neotenic features. An important fact for biogerontology is that the mortality rate of H. glaber (a maximal lifespan of more than 32 years, which is very large for such a small rodent) negligibly grows with age. The same is true for modern people in developed countries below the age of 60. It is important that the juvenilization of traits that separate humans from chimpanzees evolved over thousands of generations and millions of years. Rapid advances in technology resulted in a sharp increase in the life expectancy of human beings during the past 100 years. Currently, the human life expectancy has exceeded 80 years in developed countries. It cannot be excluded that the potential for increasing life expectancy by an improvement in living conditions will be exhausted after a certain period of time. New types of geroprotectors should be developed that protect not only from chronic phenoptosis gradual poisoning of the body with reactive oxygen species (ROS) but also from acute phenoptosis, where strong increase in the level of ROS immediately kills an already aged individual. Geroprotectors might be another anti-aging strategy along with neoteny (a natural physiological phenomenon) and technical progress. Impact Journals 2020-03-27 /pmc/articles/PMC7138562/ /pubmed/32229707 http://dx.doi.org/10.18632/aging.102981 Text en Copyright © 2020 Skulachev et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Perspective Skulachev, Vladimir P. Shilovsky, Gregory A. Putyatina, Tatyana S. Popov, Nikita A. Markov, Alexander V. Skulachev, Maxim V. Sadovnichii, Victor A. Perspectives of Homo sapiens lifespan extension: focus on external or internal resources? |
title | Perspectives of Homo sapiens lifespan extension: focus on external or internal resources? |
title_full | Perspectives of Homo sapiens lifespan extension: focus on external or internal resources? |
title_fullStr | Perspectives of Homo sapiens lifespan extension: focus on external or internal resources? |
title_full_unstemmed | Perspectives of Homo sapiens lifespan extension: focus on external or internal resources? |
title_short | Perspectives of Homo sapiens lifespan extension: focus on external or internal resources? |
title_sort | perspectives of homo sapiens lifespan extension: focus on external or internal resources? |
topic | Research Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138562/ https://www.ncbi.nlm.nih.gov/pubmed/32229707 http://dx.doi.org/10.18632/aging.102981 |
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