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Gut microbiota and pro/prebiotics in Alzheimer’s disease

Alzheimer’s disease is characterized by the accumulation of amyloid and dysfunctional tau protein in the brain along with the final development of dementia. Accumulation of amyloid in the brain was observed 10-20 years before the onset of clinical symptoms by diagnostic methods based on image analys...

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Autores principales: Pluta, Ryszard, Ułamek-Kozioł, Marzena, Januszewski, Sławomir, Czuczwar, Stanisław J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138569/
https://www.ncbi.nlm.nih.gov/pubmed/32191919
http://dx.doi.org/10.18632/aging.102930
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author Pluta, Ryszard
Ułamek-Kozioł, Marzena
Januszewski, Sławomir
Czuczwar, Stanisław J.
author_facet Pluta, Ryszard
Ułamek-Kozioł, Marzena
Januszewski, Sławomir
Czuczwar, Stanisław J.
author_sort Pluta, Ryszard
collection PubMed
description Alzheimer’s disease is characterized by the accumulation of amyloid and dysfunctional tau protein in the brain along with the final development of dementia. Accumulation of amyloid in the brain was observed 10-20 years before the onset of clinical symptoms by diagnostic methods based on image analysis. This is a serious public health problem, incidence and prevalence being expected to reach epidemic proportions over the next few decades if the disease cannot be prevented or slowed down. Recently, in addition to the strongly developing ischemic etiology of Alzheimer’s disease, it is suggested that the gut microbiota may also participate in the development of this disease. The brain and gut are thought to form a network called the “gut-brain-microbiota axis”, and it is strongly supported idea that the intestinal microflora can be involved in Alzheimer’s disease. Lately, many new studies have been conducted that draw attention to the relationship between Alzheimer’s disease and gut microbiota. This review presents a possible relationship between Alzheimer’s disease and a microbiome. It is a promising idea for prevention or therapeutic intervention. Modulation of the gut microbiota through a personalized diet or beneficial microflora intervention like pro/prebiotics, changing microbiological partners and their products, including amyloid protein, can become a new treatment for Alzheimer’s disease.
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spelling pubmed-71385692020-04-13 Gut microbiota and pro/prebiotics in Alzheimer’s disease Pluta, Ryszard Ułamek-Kozioł, Marzena Januszewski, Sławomir Czuczwar, Stanisław J. Aging (Albany NY) Review Alzheimer’s disease is characterized by the accumulation of amyloid and dysfunctional tau protein in the brain along with the final development of dementia. Accumulation of amyloid in the brain was observed 10-20 years before the onset of clinical symptoms by diagnostic methods based on image analysis. This is a serious public health problem, incidence and prevalence being expected to reach epidemic proportions over the next few decades if the disease cannot be prevented or slowed down. Recently, in addition to the strongly developing ischemic etiology of Alzheimer’s disease, it is suggested that the gut microbiota may also participate in the development of this disease. The brain and gut are thought to form a network called the “gut-brain-microbiota axis”, and it is strongly supported idea that the intestinal microflora can be involved in Alzheimer’s disease. Lately, many new studies have been conducted that draw attention to the relationship between Alzheimer’s disease and gut microbiota. This review presents a possible relationship between Alzheimer’s disease and a microbiome. It is a promising idea for prevention or therapeutic intervention. Modulation of the gut microbiota through a personalized diet or beneficial microflora intervention like pro/prebiotics, changing microbiological partners and their products, including amyloid protein, can become a new treatment for Alzheimer’s disease. Impact Journals 2020-03-19 /pmc/articles/PMC7138569/ /pubmed/32191919 http://dx.doi.org/10.18632/aging.102930 Text en Copyright © 2020 Pluta et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Pluta, Ryszard
Ułamek-Kozioł, Marzena
Januszewski, Sławomir
Czuczwar, Stanisław J.
Gut microbiota and pro/prebiotics in Alzheimer’s disease
title Gut microbiota and pro/prebiotics in Alzheimer’s disease
title_full Gut microbiota and pro/prebiotics in Alzheimer’s disease
title_fullStr Gut microbiota and pro/prebiotics in Alzheimer’s disease
title_full_unstemmed Gut microbiota and pro/prebiotics in Alzheimer’s disease
title_short Gut microbiota and pro/prebiotics in Alzheimer’s disease
title_sort gut microbiota and pro/prebiotics in alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138569/
https://www.ncbi.nlm.nih.gov/pubmed/32191919
http://dx.doi.org/10.18632/aging.102930
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