Evaluating Nelipepimut-S in the Treatment of Breast Cancer: A Short Report on the Emerging Data

Vaccine therapies for treatment and prevention of cancer have seen modest degrees of efficacy with wide variation related to the tumor type, vaccine type, adjuvants and clinical setting for their study. Over the course of the last two decades, various peptide vaccines for breast cancer have been stu...

Descripción completa

Detalles Bibliográficos
Autores principales: Dillon, Patrick M, Brenin, Christiana M, Slingluff, Craig L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138626/
https://www.ncbi.nlm.nih.gov/pubmed/32308474
http://dx.doi.org/10.2147/BCTT.S224758
_version_ 1783518609184653312
author Dillon, Patrick M
Brenin, Christiana M
Slingluff, Craig L
author_facet Dillon, Patrick M
Brenin, Christiana M
Slingluff, Craig L
author_sort Dillon, Patrick M
collection PubMed
description Vaccine therapies for treatment and prevention of cancer have seen modest degrees of efficacy with wide variation related to the tumor type, vaccine type, adjuvants and clinical setting for their study. Over the course of the last two decades, various peptide vaccines for breast cancer have been studied. The current leading peptide vaccine for human application is a HER2-based vaccine known as Nelipepimut-S, which has demonstrated immune activity and promising clinical activity in some settings. This review covers the development of this newer peptide vaccine for both HER2 amplified and non-amplified breast cancer.
format Online
Article
Text
id pubmed-7138626
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-71386262020-04-17 Evaluating Nelipepimut-S in the Treatment of Breast Cancer: A Short Report on the Emerging Data Dillon, Patrick M Brenin, Christiana M Slingluff, Craig L Breast Cancer (Dove Med Press) Review Vaccine therapies for treatment and prevention of cancer have seen modest degrees of efficacy with wide variation related to the tumor type, vaccine type, adjuvants and clinical setting for their study. Over the course of the last two decades, various peptide vaccines for breast cancer have been studied. The current leading peptide vaccine for human application is a HER2-based vaccine known as Nelipepimut-S, which has demonstrated immune activity and promising clinical activity in some settings. This review covers the development of this newer peptide vaccine for both HER2 amplified and non-amplified breast cancer. Dove 2020-04-03 /pmc/articles/PMC7138626/ /pubmed/32308474 http://dx.doi.org/10.2147/BCTT.S224758 Text en © 2020 Dillon et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Dillon, Patrick M
Brenin, Christiana M
Slingluff, Craig L
Evaluating Nelipepimut-S in the Treatment of Breast Cancer: A Short Report on the Emerging Data
title Evaluating Nelipepimut-S in the Treatment of Breast Cancer: A Short Report on the Emerging Data
title_full Evaluating Nelipepimut-S in the Treatment of Breast Cancer: A Short Report on the Emerging Data
title_fullStr Evaluating Nelipepimut-S in the Treatment of Breast Cancer: A Short Report on the Emerging Data
title_full_unstemmed Evaluating Nelipepimut-S in the Treatment of Breast Cancer: A Short Report on the Emerging Data
title_short Evaluating Nelipepimut-S in the Treatment of Breast Cancer: A Short Report on the Emerging Data
title_sort evaluating nelipepimut-s in the treatment of breast cancer: a short report on the emerging data
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138626/
https://www.ncbi.nlm.nih.gov/pubmed/32308474
http://dx.doi.org/10.2147/BCTT.S224758
work_keys_str_mv AT dillonpatrickm evaluatingnelipepimutsinthetreatmentofbreastcancerashortreportontheemergingdata
AT breninchristianam evaluatingnelipepimutsinthetreatmentofbreastcancerashortreportontheemergingdata
AT slingluffcraigl evaluatingnelipepimutsinthetreatmentofbreastcancerashortreportontheemergingdata

Ejemplares similares