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Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis
Organisms have evolved molecular mechanisms to ensure consistent and invariant phenotypes in the face of environmental fluctuations. Developmental homeostasis is determined by two factors: robustness, which buffers against environmental variations; and developmental stability, which buffers against...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138798/ https://www.ncbi.nlm.nih.gov/pubmed/32265497 http://dx.doi.org/10.1038/s42003-020-0889-1 |
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author | Matsushita, Ryota Nishimura, Takashi |
author_facet | Matsushita, Ryota Nishimura, Takashi |
author_sort | Matsushita, Ryota |
collection | PubMed |
description | Organisms have evolved molecular mechanisms to ensure consistent and invariant phenotypes in the face of environmental fluctuations. Developmental homeostasis is determined by two factors: robustness, which buffers against environmental variations; and developmental stability, which buffers against intrinsic random variations. However, our understanding of these noise-buffering mechanisms remains incomplete. Here, we showed that appropriate glycemic control confers developmental homeostasis in the fruit fly Drosophila. We found that circulating glucose levels are buffered by trehalose metabolism, which acts as a glucose sink in circulation. Furthermore, mutations in trehalose synthesis enzyme (Tps1) increased the among-individual and within-individual variations in wing size. Whereas wild-type flies were largely resistant to changes in dietary carbohydrate and protein levels, Tps1 mutants experienced significant disruptions in developmental homeostasis in response to dietary stress. These results demonstrate that glucose homeostasis against dietary stress is crucial for developmental homeostasis. |
format | Online Article Text |
id | pubmed-7138798 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-71387982020-04-13 Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis Matsushita, Ryota Nishimura, Takashi Commun Biol Article Organisms have evolved molecular mechanisms to ensure consistent and invariant phenotypes in the face of environmental fluctuations. Developmental homeostasis is determined by two factors: robustness, which buffers against environmental variations; and developmental stability, which buffers against intrinsic random variations. However, our understanding of these noise-buffering mechanisms remains incomplete. Here, we showed that appropriate glycemic control confers developmental homeostasis in the fruit fly Drosophila. We found that circulating glucose levels are buffered by trehalose metabolism, which acts as a glucose sink in circulation. Furthermore, mutations in trehalose synthesis enzyme (Tps1) increased the among-individual and within-individual variations in wing size. Whereas wild-type flies were largely resistant to changes in dietary carbohydrate and protein levels, Tps1 mutants experienced significant disruptions in developmental homeostasis in response to dietary stress. These results demonstrate that glucose homeostasis against dietary stress is crucial for developmental homeostasis. Nature Publishing Group UK 2020-04-07 /pmc/articles/PMC7138798/ /pubmed/32265497 http://dx.doi.org/10.1038/s42003-020-0889-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Matsushita, Ryota Nishimura, Takashi Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis |
title | Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis |
title_full | Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis |
title_fullStr | Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis |
title_full_unstemmed | Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis |
title_short | Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis |
title_sort | trehalose metabolism confers developmental robustness and stability in drosophila by regulating glucose homeostasis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138798/ https://www.ncbi.nlm.nih.gov/pubmed/32265497 http://dx.doi.org/10.1038/s42003-020-0889-1 |
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