Cargando…

Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis

Organisms have evolved molecular mechanisms to ensure consistent and invariant phenotypes in the face of environmental fluctuations. Developmental homeostasis is determined by two factors: robustness, which buffers against environmental variations; and developmental stability, which buffers against...

Descripción completa

Detalles Bibliográficos
Autores principales: Matsushita, Ryota, Nishimura, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138798/
https://www.ncbi.nlm.nih.gov/pubmed/32265497
http://dx.doi.org/10.1038/s42003-020-0889-1
_version_ 1783518626795487232
author Matsushita, Ryota
Nishimura, Takashi
author_facet Matsushita, Ryota
Nishimura, Takashi
author_sort Matsushita, Ryota
collection PubMed
description Organisms have evolved molecular mechanisms to ensure consistent and invariant phenotypes in the face of environmental fluctuations. Developmental homeostasis is determined by two factors: robustness, which buffers against environmental variations; and developmental stability, which buffers against intrinsic random variations. However, our understanding of these noise-buffering mechanisms remains incomplete. Here, we showed that appropriate glycemic control confers developmental homeostasis in the fruit fly Drosophila. We found that circulating glucose levels are buffered by trehalose metabolism, which acts as a glucose sink in circulation. Furthermore, mutations in trehalose synthesis enzyme (Tps1) increased the among-individual and within-individual variations in wing size. Whereas wild-type flies were largely resistant to changes in dietary carbohydrate and protein levels, Tps1 mutants experienced significant disruptions in developmental homeostasis in response to dietary stress. These results demonstrate that glucose homeostasis against dietary stress is crucial for developmental homeostasis.
format Online
Article
Text
id pubmed-7138798
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-71387982020-04-13 Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis Matsushita, Ryota Nishimura, Takashi Commun Biol Article Organisms have evolved molecular mechanisms to ensure consistent and invariant phenotypes in the face of environmental fluctuations. Developmental homeostasis is determined by two factors: robustness, which buffers against environmental variations; and developmental stability, which buffers against intrinsic random variations. However, our understanding of these noise-buffering mechanisms remains incomplete. Here, we showed that appropriate glycemic control confers developmental homeostasis in the fruit fly Drosophila. We found that circulating glucose levels are buffered by trehalose metabolism, which acts as a glucose sink in circulation. Furthermore, mutations in trehalose synthesis enzyme (Tps1) increased the among-individual and within-individual variations in wing size. Whereas wild-type flies were largely resistant to changes in dietary carbohydrate and protein levels, Tps1 mutants experienced significant disruptions in developmental homeostasis in response to dietary stress. These results demonstrate that glucose homeostasis against dietary stress is crucial for developmental homeostasis. Nature Publishing Group UK 2020-04-07 /pmc/articles/PMC7138798/ /pubmed/32265497 http://dx.doi.org/10.1038/s42003-020-0889-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Matsushita, Ryota
Nishimura, Takashi
Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis
title Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis
title_full Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis
title_fullStr Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis
title_full_unstemmed Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis
title_short Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis
title_sort trehalose metabolism confers developmental robustness and stability in drosophila by regulating glucose homeostasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138798/
https://www.ncbi.nlm.nih.gov/pubmed/32265497
http://dx.doi.org/10.1038/s42003-020-0889-1
work_keys_str_mv AT matsushitaryota trehalosemetabolismconfersdevelopmentalrobustnessandstabilityindrosophilabyregulatingglucosehomeostasis
AT nishimuratakashi trehalosemetabolismconfersdevelopmentalrobustnessandstabilityindrosophilabyregulatingglucosehomeostasis