Applicability of free drug hypothesis to drugs with good membrane permeability that are not efflux transporter substrates: A microdialysis study in rats

In clinical pharmacology, the free drug hypothesis has been widely applied in the interpretation of the relationship between pharmacokinetics and pharmacodynamics (PK/PD). The free drug hypothesis assumes that the unbound drug concentration in blood is the same as that in the site of action at stead...

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Detalles Bibliográficos
Autores principales: Chen, Chun, Zhou, Hongyu, Guan, Chi, Zhang, Huanhuan, Li, Yingying, Jiang, Xue, Dong, Zheng, Tao, Yuanyuan, Du, Juan, Wang, Shuyao, Zhang, Teng, Du, Na, Guo, Junyang, Wu, Yaqiong, Song, Zehai, Luan, Haofei, Wang, Yu, Du, Hongwen, Zhang, Shaofeng, Li, Chen, Chang, Hang, Wang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138916/
https://www.ncbi.nlm.nih.gov/pubmed/32266794
http://dx.doi.org/10.1002/prp2.575

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