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Matrix metalloproteinase family gene polymorphisms and lung cancer susceptibility: an updated meta-analysis

BACKGROUND: Many studies have investigated the association between matrix metalloproteinase polymorphisms and lung cancer susceptibility. However, the results are still controversial. To clarify these associations, we conducted a meta-analysis. METHODS: A systematic search of studies was conducted i...

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Autores principales: Li, Xiaoliang, Liu, Caiyang, Ran, Ran, Liu, Gaohua, Yang, Yanhui, Zhao, Wenzhuo, Xie, Xiaoyang, Li, Ji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138992/
https://www.ncbi.nlm.nih.gov/pubmed/32274101
http://dx.doi.org/10.21037/jtd.2020.01.25
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author Li, Xiaoliang
Liu, Caiyang
Ran, Ran
Liu, Gaohua
Yang, Yanhui
Zhao, Wenzhuo
Xie, Xiaoyang
Li, Ji
author_facet Li, Xiaoliang
Liu, Caiyang
Ran, Ran
Liu, Gaohua
Yang, Yanhui
Zhao, Wenzhuo
Xie, Xiaoyang
Li, Ji
author_sort Li, Xiaoliang
collection PubMed
description BACKGROUND: Many studies have investigated the association between matrix metalloproteinase polymorphisms and lung cancer susceptibility. However, the results are still controversial. To clarify these associations, we conducted a meta-analysis. METHODS: A systematic search of studies was conducted in PubMed, Embase, and China National Knowledge Infrastructure. Overall and subgroup analysis stratified by ethnicity was conducted. OR with 95% CI was used to assess the strength of the association. Furthermore, false-positive report probability (FPRP) tests were also performed for associations obtained in this meta-analysis. RESULTS: Twenty-four studies, including 10,099 cases and 9,395 controls, were analyzed. Nine polymorphisms were reported. For MMP1 -1607 1G/2G and MMP7 -181 A/G, increased lung cancer risk was found in Asians. For MMP2 -1306 C/T and MMP2 -735 C/T, decreased lung cancer risk was found in both “diverse populations” and Asians. For MMP9 -1562, C/T decreased lung cancer risk was found in both “diverse populations” and Caucasians. For MMP13 -77A/G, the A/G genotype decreased lung cancer risk in Asians. However, only associations between MMP1 -1607 1G/2G, MMP2 -1306 C/T, MMP2 -735 C/T, and MMP7 -181 A/G and lung cancer risk were considered noteworthy according to FPRP tests. There was no association between MMP3 -1171 5A/6A, MMP9 R279Q, and MMP12 -82A/G and lung cancer risk. CONCLUSIONS: Our meta-analysis suggested that MMP1 -1607 1G/2G and MMP7 -181 A/G were risk factors for lung cancer, while MMP2 -1306 C/T, MMP2 -735 C/T, MMP9 -1562 C/T, and MMP13 -77A/G might be protective factors. However, results for MMP9 -1562 C/T and MMP13 -77A/G should be interpreted with caution due to the probability of false-positive reports.
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spelling pubmed-71389922020-04-09 Matrix metalloproteinase family gene polymorphisms and lung cancer susceptibility: an updated meta-analysis Li, Xiaoliang Liu, Caiyang Ran, Ran Liu, Gaohua Yang, Yanhui Zhao, Wenzhuo Xie, Xiaoyang Li, Ji J Thorac Dis Original Article BACKGROUND: Many studies have investigated the association between matrix metalloproteinase polymorphisms and lung cancer susceptibility. However, the results are still controversial. To clarify these associations, we conducted a meta-analysis. METHODS: A systematic search of studies was conducted in PubMed, Embase, and China National Knowledge Infrastructure. Overall and subgroup analysis stratified by ethnicity was conducted. OR with 95% CI was used to assess the strength of the association. Furthermore, false-positive report probability (FPRP) tests were also performed for associations obtained in this meta-analysis. RESULTS: Twenty-four studies, including 10,099 cases and 9,395 controls, were analyzed. Nine polymorphisms were reported. For MMP1 -1607 1G/2G and MMP7 -181 A/G, increased lung cancer risk was found in Asians. For MMP2 -1306 C/T and MMP2 -735 C/T, decreased lung cancer risk was found in both “diverse populations” and Asians. For MMP9 -1562, C/T decreased lung cancer risk was found in both “diverse populations” and Caucasians. For MMP13 -77A/G, the A/G genotype decreased lung cancer risk in Asians. However, only associations between MMP1 -1607 1G/2G, MMP2 -1306 C/T, MMP2 -735 C/T, and MMP7 -181 A/G and lung cancer risk were considered noteworthy according to FPRP tests. There was no association between MMP3 -1171 5A/6A, MMP9 R279Q, and MMP12 -82A/G and lung cancer risk. CONCLUSIONS: Our meta-analysis suggested that MMP1 -1607 1G/2G and MMP7 -181 A/G were risk factors for lung cancer, while MMP2 -1306 C/T, MMP2 -735 C/T, MMP9 -1562 C/T, and MMP13 -77A/G might be protective factors. However, results for MMP9 -1562 C/T and MMP13 -77A/G should be interpreted with caution due to the probability of false-positive reports. AME Publishing Company 2020-03 /pmc/articles/PMC7138992/ /pubmed/32274101 http://dx.doi.org/10.21037/jtd.2020.01.25 Text en 2020 Journal of Thoracic Disease. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Li, Xiaoliang
Liu, Caiyang
Ran, Ran
Liu, Gaohua
Yang, Yanhui
Zhao, Wenzhuo
Xie, Xiaoyang
Li, Ji
Matrix metalloproteinase family gene polymorphisms and lung cancer susceptibility: an updated meta-analysis
title Matrix metalloproteinase family gene polymorphisms and lung cancer susceptibility: an updated meta-analysis
title_full Matrix metalloproteinase family gene polymorphisms and lung cancer susceptibility: an updated meta-analysis
title_fullStr Matrix metalloproteinase family gene polymorphisms and lung cancer susceptibility: an updated meta-analysis
title_full_unstemmed Matrix metalloproteinase family gene polymorphisms and lung cancer susceptibility: an updated meta-analysis
title_short Matrix metalloproteinase family gene polymorphisms and lung cancer susceptibility: an updated meta-analysis
title_sort matrix metalloproteinase family gene polymorphisms and lung cancer susceptibility: an updated meta-analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138992/
https://www.ncbi.nlm.nih.gov/pubmed/32274101
http://dx.doi.org/10.21037/jtd.2020.01.25
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