Cargando…

Knockdown of PLAT enhances the anticancer effect of gefitinib in non-small cell lung cancer

BACKGROUND: Tyrosine kinase inhibitors (TKIs), such as gefitinib, are widely used as standard treatments for non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations. However, the subsequent inevitable drug resistance has become a major challenge in clinical...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yan, Mengnan, Wang, Wei, Zhou, Jian, Chang, Meijia, Peng, Wenjun, Zhang, Ge, Li, Jing, Li, Huayin, Bai, Chunxue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139041/ https://www.ncbi.nlm.nih.gov/pubmed/32274137 http://dx.doi.org/10.21037/jtd.2019.12.106

Ejemplares similares

Knockdown of annexin A5 restores gefitinib sensitivity by promoting G2/M cell cycle arrest
por: Zhou, Jian, et al.
Publicado: (2018)

Calpain 2 knockdown promotes cell apoptosis and restores gefitinib sensitivity through epidermal growth factor receptor/protein kinase B/survivin signaling
por: Zhang, Ge, et al.
Publicado: (2018)

Plat du jour – Short Films!
por: Claudia Marcelloni
Publicado: (2014)

Glycerol kinase 5 confers gefitinib resistance through SREBP1/SCD1 signaling pathway
por: Zhou, Jian, et al.
Publicado: (2019)

ADAM9 promotes lung cancer progression through vascular remodeling by VEGFA, ANGPT2, and PLAT
por: Lin, Chen-Yuan, et al.
Publicado: (2017)

Anticancer Effects of Amlodipine Alone or in Combination With Gefitinib in Non-Small Cell Lung Cancer
por: Fu, Bingjie, et al.
Publicado: (2022)

Condylomes plats vulvaires comme premières manifestations de la syphilis
por: Robillard, Justine, et al.
Publicado: (2023)

The Arabidopsis PLAT Domain Protein1 Is Critically Involved in Abiotic Stress Tolerance
por: Hyun, Tae Kyung, et al.
Publicado: (2014)

FBP1 induced by β‐elemene enhances the sensitivity of gefitinib in lung cancer
por: Li, Jian, et al.
Publicado: (2022)

miR-762 activation confers acquired resistance to gefitinib in non-small cell lung cancer
por: Ge, Peng, et al.
Publicado: (2019)

Gefitinib in Non Small Cell Lung Cancer
por: Costanzo, Raffaele, et al.
Publicado: (2011)

PLAT: An Automated Fault and Behavioural Anomaly Detection Tool for PLC Controlled Manufacturing Systems
por: Ghosh, Arup, et al.
Publicado: (2016)

Processus d’accréditation : les LBM prêchent la mise à plat immédiate
por: Benaderette, Serge
Publicado: (2020)

ProtPlat: an efficient pre-training platform for protein classification based on FastText
por: Jin, Yuan, et al.
Publicado: (2022)

Chloroquine Enhances Gefitinib Cytotoxicity in Gefitinib-Resistant Nonsmall Cell Lung Cancer Cells
por: Tang, Mei-Chuan, et al.
Publicado: (2015)

Clinical benefit of readministration of gefitinib for initial gefitinib-responders with non-small cell lung cancer
por: Yokouchi, Hiroshi, et al.
Publicado: (2007)

Anticancer Effects of Paris Saponins by Apoptosis and PI3K/AKT Pathway in Gefitinib-Resistant Non-Small Cell Lung Cancer
por: Zhu, Xinhai, et al.
Publicado: (2016)

Low Expression of PLAT in Breast Cancer Infers Poor Prognosis and High Immune Infiltrating Level
por: Wang, Xinyang, et al.
Publicado: (2021)

Ex Vivo Production of Platelets From iPSCs: The iPLAT1 Study and Beyond
por: Sugimoto, Naoshi, et al.
Publicado: (2023)

GLIPR1 modulates the response of cisplatin-resistant human lung cancer cells to cisplatin
por: Gong, Xin, et al.
Publicado: (2017)

Phase I study of irinotecan and gefitinib in patients with gefitinib treatment failure for non-small cell lung cancer
por: Horiike, A, et al.
Publicado: (2011)

Multiomics Integration in Skin Diseases with Alterations in Notch Signaling Pathway: PlatOMICs Phase 1 Deployment
por: Brandão, Lucas André Cavalcanti, et al.
Publicado: (2021)

Drug resistance analysis of gefitinib-targeted therapy in non-small cell lung cancer
por: Liu, Shuliang, et al.
Publicado: (2016)

ERK inhibition represses gefitinib resistance in non-small cell lung cancer cells
por: Qi, Mengfan, et al.
Publicado: (2018)

Review of the Treatment of Non-Small Cell Lung Cancer with Gefitinib
por: Araki, Takuya, et al.
Publicado: (2012)

The Effects and Mechanisms by which Saikosaponin-D Enhances the Sensitivity of Human Non-small Cell Lung Cancer Cells to Gefitinib
por: Tang, Jian-cai, et al.
Publicado: (2019)

PI-Plat: a high-resolution image-based 3D reconstruction method to estimate growth dynamics of rice inflorescence traits
por: Sandhu, Jaspreet, et al.
Publicado: (2019)

KLHL5 knockdown increases cellular sensitivity to anticancer drugs
por: Schleifer, Robert J., et al.
Publicado: (2018)

Cost-Effectiveness Analysis of Gefitinib Plus Chemotherapy versus Gefitinib Alone for Advanced Non-Small-Cell Lung Cancer with EGFR Mutations in China
por: Shu, Yamin, et al.
Publicado: (2021)

Losmapimod Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer by Preventing Tetraploidization
por: Yeung, Yiu To, et al.
Publicado: (2018)

Production and nonclinical evaluation of an autologous iPSC–derived platelet product for the iPLAT1 clinical trial
por: Sugimoto, Naoshi, et al.
Publicado: (2022)

Potential roles of tumor microenvironment in gefitinib-resistant non-small cell lung cancer: A narrative review
por: Chen, Mu-Tong, et al.
Publicado: (2023)

AT-101 enhances gefitinib sensitivity in non-small cell lung cancer with EGFR T790M mutations
por: Zhao, Ren, et al.
Publicado: (2016)

Randomized, Multicenter Study of Gefitinib Dose-escalation in Advanced Non-small-cell Lung Cancer Patients Achieved Stable Disease after One-month Gefitinib Treatment
por: Xue, Cong, et al.
Publicado: (2015)

Role of gefitinib in the targeted treatment of non-small-cell lung cancer in Chinese patients
por: Li, Meng-Jiao, et al.
Publicado: (2016)

Increased glutamine anabolism sensitizes non-small cell lung cancer to gefitinib treatment
por: Wang, Liang, et al.
Publicado: (2018)

Efficacy of chemotherapy plus gefitinib treatment in advanced non-small-cell lung cancer patients following acquired resistance to gefitinib
por: SONG, ZHENGBO, et al.
Publicado: (2013)

Comparison of gefitinib plus chemotherapy versus gefitinib alone for advanced non‑small‑cell lung cancer: A meta analysis
por: Yi, Min, et al.
Publicado: (2023)

Inhibiting proliferation of gefitinib-resistant, non-small cell lung cancer
por: Sudo, Makoto, et al.
Publicado: (2013)

Erratum in: Review of the Treatment of Non-Small Cell Lung Cancer with Gefitinib
por: Araki, Takuya, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_3ss641te1ersa60leblkuqqmnm