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Soft ultrasound priors in optoacoustic reconstruction: Improving clinical vascular imaging
Using the same ultrasound detector, hybrid optoacoustic-ultrasound (OPUS) imaging provides concurrent scans of tissue slices or volumes and visualizes complementary sound- and light-based contrast at similar resolutions. In addition to the benefit of hybrid contrast, spatial co-registration enables...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139114/ https://www.ncbi.nlm.nih.gov/pubmed/32280585 http://dx.doi.org/10.1016/j.pacs.2020.100172 |
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author | Yang, Hong Jüstel, Dominik Prakash, Jaya Karlas, Angelos Helfen, Anne Masthoff, Max Wildgruber, Moritz Ntziachristos, Vasilis |
author_facet | Yang, Hong Jüstel, Dominik Prakash, Jaya Karlas, Angelos Helfen, Anne Masthoff, Max Wildgruber, Moritz Ntziachristos, Vasilis |
author_sort | Yang, Hong |
collection | PubMed |
description | Using the same ultrasound detector, hybrid optoacoustic-ultrasound (OPUS) imaging provides concurrent scans of tissue slices or volumes and visualizes complementary sound- and light-based contrast at similar resolutions. In addition to the benefit of hybrid contrast, spatial co-registration enables images from one modality to be employed as prior information for improving an aspect of the performance of the other modality. We consider herein a handheld OPUS system and utilize structural information from ultrasound images to guide regional Laplacian regularization-based reconstruction of optoacoustic images. Using phantoms and data from OPUS scans of human radial and carotid arteries, we show that ultrasound-driven optoacoustic inversion reduces limited-view artefacts and improves image contrast. In phantoms, prior-integrated reconstruction leads to a 50 % higher contrast-to-noise ratio (CNR) of the image than standard reconstruction, and a 17 % higher structural similarity (SSIM) index. In clinical data, prior-integrated reconstruction detects deep-seated radial arteries with higher CNR than the standard method at three different depths. In this way, the prior-integrated method offers unique insights into atherosclerotic carotid plaques in humans (with p<0.01 between patients and healthy volunteers), potentially paving the way for new abilities in vascular imaging and more generally in optoacoustic imaging. |
format | Online Article Text |
id | pubmed-7139114 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-71391142020-04-10 Soft ultrasound priors in optoacoustic reconstruction: Improving clinical vascular imaging Yang, Hong Jüstel, Dominik Prakash, Jaya Karlas, Angelos Helfen, Anne Masthoff, Max Wildgruber, Moritz Ntziachristos, Vasilis Photoacoustics Research Article Using the same ultrasound detector, hybrid optoacoustic-ultrasound (OPUS) imaging provides concurrent scans of tissue slices or volumes and visualizes complementary sound- and light-based contrast at similar resolutions. In addition to the benefit of hybrid contrast, spatial co-registration enables images from one modality to be employed as prior information for improving an aspect of the performance of the other modality. We consider herein a handheld OPUS system and utilize structural information from ultrasound images to guide regional Laplacian regularization-based reconstruction of optoacoustic images. Using phantoms and data from OPUS scans of human radial and carotid arteries, we show that ultrasound-driven optoacoustic inversion reduces limited-view artefacts and improves image contrast. In phantoms, prior-integrated reconstruction leads to a 50 % higher contrast-to-noise ratio (CNR) of the image than standard reconstruction, and a 17 % higher structural similarity (SSIM) index. In clinical data, prior-integrated reconstruction detects deep-seated radial arteries with higher CNR than the standard method at three different depths. In this way, the prior-integrated method offers unique insights into atherosclerotic carotid plaques in humans (with p<0.01 between patients and healthy volunteers), potentially paving the way for new abilities in vascular imaging and more generally in optoacoustic imaging. Elsevier 2020-03-10 /pmc/articles/PMC7139114/ /pubmed/32280585 http://dx.doi.org/10.1016/j.pacs.2020.100172 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Yang, Hong Jüstel, Dominik Prakash, Jaya Karlas, Angelos Helfen, Anne Masthoff, Max Wildgruber, Moritz Ntziachristos, Vasilis Soft ultrasound priors in optoacoustic reconstruction: Improving clinical vascular imaging |
title | Soft ultrasound priors in optoacoustic reconstruction: Improving clinical vascular imaging |
title_full | Soft ultrasound priors in optoacoustic reconstruction: Improving clinical vascular imaging |
title_fullStr | Soft ultrasound priors in optoacoustic reconstruction: Improving clinical vascular imaging |
title_full_unstemmed | Soft ultrasound priors in optoacoustic reconstruction: Improving clinical vascular imaging |
title_short | Soft ultrasound priors in optoacoustic reconstruction: Improving clinical vascular imaging |
title_sort | soft ultrasound priors in optoacoustic reconstruction: improving clinical vascular imaging |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139114/ https://www.ncbi.nlm.nih.gov/pubmed/32280585 http://dx.doi.org/10.1016/j.pacs.2020.100172 |
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