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Epigenetic activation of O-linked β-N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia

BACKGROUND: Overriding the differentiation blockage in acute myeloid leukemia (AML) is the most successful mode-of-action in leukemia therapy – now curing the vast majority of patients with acute promyelocytic leukemia (APL) using all-trans retinoic acid (ATRA)-based regimens. Similar approaches in...

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Detalles Bibliográficos
Autores principales:	Kampa-Schittenhelm, K.M., Haverkamp, T., Bonin, M., Tsintari, V., Bühring, H.J., Haeusser, L., Blumenstock, G., Dreher, S.T., Ganief, T., Akmut, F., Illing, B., Mau-Holzmann, U.A., Bonzheim, I., Schleicher, E., Vogel, W., Schittenhelm, M.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139116/ https://www.ncbi.nlm.nih.gov/pubmed/32272438 http://dx.doi.org/10.1016/j.ebiom.2020.102678

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