Ancestrally Duplicated Conserved Noncoding Element Suggests Dual Regulatory Roles of HOTAIR in cis and trans

HOTAIR was proposed to regulate either HoxD cluster genes in trans or HoxC cluster genes in cis, a mechanism that remains unclear. We have identified a 32-nucleotide conserved noncoding element (CNE) as HOTAIR ancient sequence that likely originated at the root of vertebrate. The second round of who...

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Detalles Bibliográficos
Autores principales: Nepal, Chirag, Taranta, Andrzej, Hadzhiev, Yavor, Pundhir, Sachin, Mydel, Piotr, Lenhard, Boris, Müller, Ferenc, Andersen, Jesper B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139118/
https://www.ncbi.nlm.nih.gov/pubmed/32268280
http://dx.doi.org/10.1016/j.isci.2020.101008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139118/
https://www.ncbi.nlm.nih.gov/pubmed/32268280
http://dx.doi.org/10.1016/j.isci.2020.101008

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