Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2

Rab8a is associated with the dynamic regulation of membrane protrusions in polarized cells. Rab8a is one of several Rab GTPases that are substrates of leucine-rich repeat kinase 2 (LRRK2), a serine/threonine kinase that is linked to Parkinson's disease. Rab8a is phosphorylated at T72 (pT72) in...

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Detalles Bibliográficos
Autores principales: Waschbüsch, Dieter, Purlyte, Elena, Pal, Prosenjit, McGrath, Emma, Alessi, Dario R., Khan, Amir R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139218/
https://www.ncbi.nlm.nih.gov/pubmed/32017888
http://dx.doi.org/10.1016/j.str.2020.01.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139218/
https://www.ncbi.nlm.nih.gov/pubmed/32017888
http://dx.doi.org/10.1016/j.str.2020.01.005

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