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How Does Epstein–Barr Virus Contribute to Chronic Periodontitis?

Chronic periodontitis is spreading worldwide and mutually interacts with systemic diseases like diabetes mellitus. Although periodontopathic bacteria are inevitable pathogens in their onset and progression, many cases are not ascribable to the virulence of these bacteria because the effect of plaque...

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Detalles Bibliográficos
Autores principales: Imai, Kenichi, Ogata, Yorimasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139403/
https://www.ncbi.nlm.nih.gov/pubmed/32178406
http://dx.doi.org/10.3390/ijms21061940
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author Imai, Kenichi
Ogata, Yorimasa
author_facet Imai, Kenichi
Ogata, Yorimasa
author_sort Imai, Kenichi
collection PubMed
description Chronic periodontitis is spreading worldwide and mutually interacts with systemic diseases like diabetes mellitus. Although periodontopathic bacteria are inevitable pathogens in their onset and progression, many cases are not ascribable to the virulence of these bacteria because the effect of plaque control is limited. In contrast, Epstein–Barr virus (EBV) in the periodontium has been correlated with chronic periodontitis and has recently been considered as a promising pathogenic candidate for this disease. However, several important questions have yet to be addressed. For instance, although EBV latently infects more than 90% of individuals over the world, why do patients with chronic periodontitis exclusively harbor progeny EBV in the oral cavity? In addition, how does latently infected or reactivated EBV in the periodontium relate to the onset or progression of chronic periodontitis? Finally, is periodontitis incurable because EBV is the pathogen for chronic periodontitis? In this review, we attempt to answer these questions by reporting the current understanding of molecular relations and mechanisms between periodontopathic bacteria and EBV reactivation in the context of how this relationship may pertain to the etiology of chronic periodontitis.
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spelling pubmed-71394032020-04-10 How Does Epstein–Barr Virus Contribute to Chronic Periodontitis? Imai, Kenichi Ogata, Yorimasa Int J Mol Sci Review Chronic periodontitis is spreading worldwide and mutually interacts with systemic diseases like diabetes mellitus. Although periodontopathic bacteria are inevitable pathogens in their onset and progression, many cases are not ascribable to the virulence of these bacteria because the effect of plaque control is limited. In contrast, Epstein–Barr virus (EBV) in the periodontium has been correlated with chronic periodontitis and has recently been considered as a promising pathogenic candidate for this disease. However, several important questions have yet to be addressed. For instance, although EBV latently infects more than 90% of individuals over the world, why do patients with chronic periodontitis exclusively harbor progeny EBV in the oral cavity? In addition, how does latently infected or reactivated EBV in the periodontium relate to the onset or progression of chronic periodontitis? Finally, is periodontitis incurable because EBV is the pathogen for chronic periodontitis? In this review, we attempt to answer these questions by reporting the current understanding of molecular relations and mechanisms between periodontopathic bacteria and EBV reactivation in the context of how this relationship may pertain to the etiology of chronic periodontitis. MDPI 2020-03-12 /pmc/articles/PMC7139403/ /pubmed/32178406 http://dx.doi.org/10.3390/ijms21061940 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Imai, Kenichi
Ogata, Yorimasa
How Does Epstein–Barr Virus Contribute to Chronic Periodontitis?
title How Does Epstein–Barr Virus Contribute to Chronic Periodontitis?
title_full How Does Epstein–Barr Virus Contribute to Chronic Periodontitis?
title_fullStr How Does Epstein–Barr Virus Contribute to Chronic Periodontitis?
title_full_unstemmed How Does Epstein–Barr Virus Contribute to Chronic Periodontitis?
title_short How Does Epstein–Barr Virus Contribute to Chronic Periodontitis?
title_sort how does epstein–barr virus contribute to chronic periodontitis?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139403/
https://www.ncbi.nlm.nih.gov/pubmed/32178406
http://dx.doi.org/10.3390/ijms21061940
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