Synthetic Lethality Screening Identifies FDA-Approved Drugs that Overcome ATP7B-Mediated Tolerance of Tumor Cells to Cisplatin

Tumor resistance to chemotherapy represents an important challenge in modern oncology. Although platinum (Pt)-based drugs have demonstrated excellent therapeutic potential, their effectiveness in a wide range of tumors is limited by the development of resistance mechanisms. One of these mechanisms i...

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Detalles Bibliográficos
Autores principales: Mariniello, Marta, Petruzzelli, Raffaella, Wanderlingh, Luca G., La Montagna, Raffaele, Carissimo, Annamaria, Pane, Francesca, Amoresano, Angela, Ilyechova, Ekaterina Y., Galagudza, Michael M., Catalano, Federico, Crispino, Roberta, Puchkova, Ludmila V., Medina, Diego L., Polishchuk, Roman S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139527/
https://www.ncbi.nlm.nih.gov/pubmed/32155756
http://dx.doi.org/10.3390/cancers12030608

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