Cargando…

PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice

Peroxisome proliferator-activated receptor (PPAR) α, β/δ, and γ modulate lipid homeostasis. PPARα regulates lipid metabolism in the liver, the organ that largely controls whole-body nutrient/energy homeostasis, and its abnormalities may lead to hepatic steatosis, steatohepatitis, steatofibrosis, and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yaping, Nakajima, Takero, Gonzalez, Frank J., Tanaka, Naoki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139552/ https://www.ncbi.nlm.nih.gov/pubmed/32192216 http://dx.doi.org/10.3390/ijms21062061

Ejemplares similares

Hepatic Cerebroside Sulfotransferase Is Induced by PPARα Activation in Mice
por: Kimura, Takefumi, et al.
Publicado: (2012)

Metabolomics of the interaction between PPAR-α and age in the PPAR-α-null mouse
por: Atherton, Helen J, et al.
Publicado: (2009)

PPARs and Liver Disease
por: Kondo, Yasuteru, et al.
Publicado: (2013)

PPARβ Regulates Liver Regeneration by Modulating Akt and E2f Signaling
por: Liu, Hui-Xin, et al.
Publicado: (2013)

Nephropathy in Pparg-null mice highlights PPARγ systemic activities in metabolism and in the immune system
por: Toffoli, Barbara, et al.
Publicado: (2017)

Fatty Acid Accumulation and Resulting PPARα Activation in Fibroblasts due to Trifunctional Protein Deficiency
por: Wakabayashi, Masato, et al.
Publicado: (2012)

PPARs as Metabolic Sensors and Therapeutic Targets in Liver Diseases
por: Monroy-Ramirez, Hugo Christian, et al.
Publicado: (2021)

Gene Expression Profiling in Wild-Type and PPARα-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPARα-Independent Effects
por: Rosen, Mitchell B., et al.
Publicado: (2010)

Clinically Relevant Dose of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα), Lowers Serum Triglyceride Levels by Targeting Hepatic PPARα in Mice
por: Zhang, Zhe, et al.
Publicado: (2022)

Transcriptional profiling of PPARα−/− and CREB3L3−/− livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPARα
por: Ruppert, Philip M. M., et al.
Publicado: (2019)

Effects of PPARs Agonists on Cardiac Metabolism in Littermate and Cardiomyocyte-Specific PPAR-γ –Knockout (CM-PGKO) Mice
por: Barbieri, Michelangela, et al.
Publicado: (2012)

PPARα Induces the Expression of CAR That Works as a Negative Regulator of PPARα Functions in Mouse Livers
por: Shizu, Ryota, et al.
Publicado: (2023)

PPARs in Liver Diseases and Cancer: Epigenetic Regulation by MicroRNAs
por: Peyrou, Marion, et al.
Publicado: (2012)

Differential Response to Trichloroethylene-Induced Hepatosteatosis in Wild-Type and PPARα-Humanized Mice
por: Ramdhan, Doni Hikmat, et al.
Publicado: (2010)

Activation of PXR, CAR and PPARα by pyrethroid pesticides and the effect of metabolism by rat liver microsomes
por: Fujino, Chieri, et al.
Publicado: (2019)

The Role of PPARα Activation in Liver and Muscle
por: Burri, Lena, et al.
Publicado: (2010)

PPAR and Liver Injury in HIV-Infected Patients
por: Lemoine, Maud, et al.
Publicado: (2009)

Isoform-specific functions of PPARγ in gene regulation and metabolism
por: Hu, Wenxiang, et al.
Publicado: (2022)

Hepatocyte-Specific Loss of PPARγ Protects Mice From NASH and Increases the Therapeutic Effects of Rosiglitazone in the Liver
por: Lee, Samuel M., et al.
Publicado: (2021)

PPARs and Bone Metabolism
por: Lecka-Czernik, Beata
Publicado: (2006)

PPARs and Metabolic Syndrome
por: Chen, Lihong, et al.
Publicado: (2014)

Cardiomyocyte-Restricted Deletion of PPARβ/δ in PPARα-Null Mice Causes Impaired Mitochondrial Biogenesis and Defense, but No Further Depression of Myocardial Fatty Acid Oxidation
por: Liu, Jian, et al.
Publicado: (2011)

PPARα Is Required for PPARδ Action in Regulation of Body Weight and Hepatic Steatosis in Mice
por: Garbacz, Wojciech G., et al.
Publicado: (2015)

MDG-1, a Potential Regulator of PPARα and PPARγ, Ameliorates Dyslipidemia in Mice
por: Wang, Xu, et al.
Publicado: (2017)

Update on Pparγ and Nonalcoholic Fatty Liver Disease
por: Ables, Gene P.
Publicado: (2012)

Metabolomics dataset of PPAR-pan treated rat liver
por: Ament, Zsuzsanna, et al.
Publicado: (2016)

Sex-specific regulation of immune responses by PPARs
por: Park, Hong-Jai, et al.
Publicado: (2017)

Regulation of Bile Acid and Cholesterol Metabolism by PPARs
por: Li, Tiangang, et al.
Publicado: (2009)

AMPK-Dependent Metabolic Regulation by PPAR Agonists
por: Lee, Woo Hyung, et al.
Publicado: (2010)

PPARs as Key Mediators in the Regulation of Metabolism and Inflammation
por: Vázquez-Carrera, Manuel, et al.
Publicado: (2022)

A Retrospective on Nuclear Receptor Regulation of Inflammation: Lessons from GR and PPARs
por: Li, Min-Dian, et al.
Publicado: (2011)

The whole transcriptome effects of the PPARα agonist fenofibrate on livers of hepatocyte humanized mice
por: de la Rosa Rodriguez, Montserrat A., et al.
Publicado: (2018)

PPAR Alpha as a Metabolic Modulator of the Liver: Role in the Pathogenesis of Nonalcoholic Steatohepatitis (NASH)
por: Todisco, Simona, et al.
Publicado: (2022)

The PPARα and PPARγ Epigenetic Landscape in Cancer and Immune and Metabolic Disorders
por: Porcuna, Jesús, et al.
Publicado: (2021)

PPARα activation protects against cholestatic liver injury
por: Zhao, Qi, et al.
Publicado: (2017)

Modulation of liver steatosis by miR-21/PPARα
por: Rodrigues, Pedro M., et al.
Publicado: (2018)

Therapeutic potential of PPARγ natural agonists in liver diseases
por: Wu, Liwei, et al.
Publicado: (2020)

Hypoxia via ERK Signaling Inhibits Hepatic PPARα to Promote Fatty Liver
por: Mooli, Raja Gopal Reddy, et al.
Publicado: (2021)

Atorvastatin Ester Regulates Lipid Metabolism in Hyperlipidemia Rats via the PPAR-signaling Pathway and HMGCR Expression in the Liver
por: Hu, Nan, et al.
Publicado: (2021)

Impaired skin wound healing in peroxisome proliferator–activated receptor (PPAR)α and PPARβ mutant mice
por: Michalik, Liliane, et al.
Publicado: (2001)

Cannot write session to /tmp/vufind_sessions/sess_pjgcbgd0pr1r1i42kcdj7502te