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The Fibroblast Growth Factor Receptors in Breast Cancer: from Oncogenesis to Better Treatments
Breast cancer (BC) is the most frequent form of malignancy and second only to lung cancer as cause of deaths in women. Notwithstanding many progresses made in the field, metastatic BC has a very poor prognosis. As therapies are becoming more personalized to meet the needs of patients, a better knowl...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139621/ https://www.ncbi.nlm.nih.gov/pubmed/32188012 http://dx.doi.org/10.3390/ijms21062011 |
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author | Sobhani, Navid Fan, Chunmei O. Flores-Villanueva, Pedro Generali, Daniele Li, Yong |
author_facet | Sobhani, Navid Fan, Chunmei O. Flores-Villanueva, Pedro Generali, Daniele Li, Yong |
author_sort | Sobhani, Navid |
collection | PubMed |
description | Breast cancer (BC) is the most frequent form of malignancy and second only to lung cancer as cause of deaths in women. Notwithstanding many progresses made in the field, metastatic BC has a very poor prognosis. As therapies are becoming more personalized to meet the needs of patients, a better knowledge of the molecular biology leading to the disease unfolds the possibility to project more precise compounds or antibodies targeting definite alteration at the molecular level and functioning on such cancer-causing molecules expressed in cancer cells of patients, or present as antigens on the surface of cancer cell membranes. Fibroblast growth factor receptor (FGFR) is one of such druggable targets, activated by its own ligands -namely the Fibroblast Growth Factors (FGFs). This pathway provides a vast range of interesting molecular targets pursued at different levels of clinical investigation. Herein we provide an update on the knowledge of genetic alterations of the receptors in breast cancer, their role in tumorigenesis and the most recent drugs against this particular receptor for the treatment of the disease. |
format | Online Article Text |
id | pubmed-7139621 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71396212020-04-10 The Fibroblast Growth Factor Receptors in Breast Cancer: from Oncogenesis to Better Treatments Sobhani, Navid Fan, Chunmei O. Flores-Villanueva, Pedro Generali, Daniele Li, Yong Int J Mol Sci Review Breast cancer (BC) is the most frequent form of malignancy and second only to lung cancer as cause of deaths in women. Notwithstanding many progresses made in the field, metastatic BC has a very poor prognosis. As therapies are becoming more personalized to meet the needs of patients, a better knowledge of the molecular biology leading to the disease unfolds the possibility to project more precise compounds or antibodies targeting definite alteration at the molecular level and functioning on such cancer-causing molecules expressed in cancer cells of patients, or present as antigens on the surface of cancer cell membranes. Fibroblast growth factor receptor (FGFR) is one of such druggable targets, activated by its own ligands -namely the Fibroblast Growth Factors (FGFs). This pathway provides a vast range of interesting molecular targets pursued at different levels of clinical investigation. Herein we provide an update on the knowledge of genetic alterations of the receptors in breast cancer, their role in tumorigenesis and the most recent drugs against this particular receptor for the treatment of the disease. MDPI 2020-03-16 /pmc/articles/PMC7139621/ /pubmed/32188012 http://dx.doi.org/10.3390/ijms21062011 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sobhani, Navid Fan, Chunmei O. Flores-Villanueva, Pedro Generali, Daniele Li, Yong The Fibroblast Growth Factor Receptors in Breast Cancer: from Oncogenesis to Better Treatments |
title | The Fibroblast Growth Factor Receptors in Breast Cancer: from Oncogenesis to Better Treatments |
title_full | The Fibroblast Growth Factor Receptors in Breast Cancer: from Oncogenesis to Better Treatments |
title_fullStr | The Fibroblast Growth Factor Receptors in Breast Cancer: from Oncogenesis to Better Treatments |
title_full_unstemmed | The Fibroblast Growth Factor Receptors in Breast Cancer: from Oncogenesis to Better Treatments |
title_short | The Fibroblast Growth Factor Receptors in Breast Cancer: from Oncogenesis to Better Treatments |
title_sort | fibroblast growth factor receptors in breast cancer: from oncogenesis to better treatments |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139621/ https://www.ncbi.nlm.nih.gov/pubmed/32188012 http://dx.doi.org/10.3390/ijms21062011 |
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