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The Fibroblast Growth Factor Receptors in Breast Cancer: from Oncogenesis to Better Treatments

Breast cancer (BC) is the most frequent form of malignancy and second only to lung cancer as cause of deaths in women. Notwithstanding many progresses made in the field, metastatic BC has a very poor prognosis. As therapies are becoming more personalized to meet the needs of patients, a better knowl...

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Detalles Bibliográficos
Autores principales: Sobhani, Navid, Fan, Chunmei, O. Flores-Villanueva, Pedro, Generali, Daniele, Li, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139621/
https://www.ncbi.nlm.nih.gov/pubmed/32188012
http://dx.doi.org/10.3390/ijms21062011
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author Sobhani, Navid
Fan, Chunmei
O. Flores-Villanueva, Pedro
Generali, Daniele
Li, Yong
author_facet Sobhani, Navid
Fan, Chunmei
O. Flores-Villanueva, Pedro
Generali, Daniele
Li, Yong
author_sort Sobhani, Navid
collection PubMed
description Breast cancer (BC) is the most frequent form of malignancy and second only to lung cancer as cause of deaths in women. Notwithstanding many progresses made in the field, metastatic BC has a very poor prognosis. As therapies are becoming more personalized to meet the needs of patients, a better knowledge of the molecular biology leading to the disease unfolds the possibility to project more precise compounds or antibodies targeting definite alteration at the molecular level and functioning on such cancer-causing molecules expressed in cancer cells of patients, or present as antigens on the surface of cancer cell membranes. Fibroblast growth factor receptor (FGFR) is one of such druggable targets, activated by its own ligands -namely the Fibroblast Growth Factors (FGFs). This pathway provides a vast range of interesting molecular targets pursued at different levels of clinical investigation. Herein we provide an update on the knowledge of genetic alterations of the receptors in breast cancer, their role in tumorigenesis and the most recent drugs against this particular receptor for the treatment of the disease.
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spelling pubmed-71396212020-04-10 The Fibroblast Growth Factor Receptors in Breast Cancer: from Oncogenesis to Better Treatments Sobhani, Navid Fan, Chunmei O. Flores-Villanueva, Pedro Generali, Daniele Li, Yong Int J Mol Sci Review Breast cancer (BC) is the most frequent form of malignancy and second only to lung cancer as cause of deaths in women. Notwithstanding many progresses made in the field, metastatic BC has a very poor prognosis. As therapies are becoming more personalized to meet the needs of patients, a better knowledge of the molecular biology leading to the disease unfolds the possibility to project more precise compounds or antibodies targeting definite alteration at the molecular level and functioning on such cancer-causing molecules expressed in cancer cells of patients, or present as antigens on the surface of cancer cell membranes. Fibroblast growth factor receptor (FGFR) is one of such druggable targets, activated by its own ligands -namely the Fibroblast Growth Factors (FGFs). This pathway provides a vast range of interesting molecular targets pursued at different levels of clinical investigation. Herein we provide an update on the knowledge of genetic alterations of the receptors in breast cancer, their role in tumorigenesis and the most recent drugs against this particular receptor for the treatment of the disease. MDPI 2020-03-16 /pmc/articles/PMC7139621/ /pubmed/32188012 http://dx.doi.org/10.3390/ijms21062011 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sobhani, Navid
Fan, Chunmei
O. Flores-Villanueva, Pedro
Generali, Daniele
Li, Yong
The Fibroblast Growth Factor Receptors in Breast Cancer: from Oncogenesis to Better Treatments
title The Fibroblast Growth Factor Receptors in Breast Cancer: from Oncogenesis to Better Treatments
title_full The Fibroblast Growth Factor Receptors in Breast Cancer: from Oncogenesis to Better Treatments
title_fullStr The Fibroblast Growth Factor Receptors in Breast Cancer: from Oncogenesis to Better Treatments
title_full_unstemmed The Fibroblast Growth Factor Receptors in Breast Cancer: from Oncogenesis to Better Treatments
title_short The Fibroblast Growth Factor Receptors in Breast Cancer: from Oncogenesis to Better Treatments
title_sort fibroblast growth factor receptors in breast cancer: from oncogenesis to better treatments
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139621/
https://www.ncbi.nlm.nih.gov/pubmed/32188012
http://dx.doi.org/10.3390/ijms21062011
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