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Increased Resting State Triple Network Functional Connectivity in Undergraduate Problematic Cannabis Users: A Preliminary EEG Coherence Study
An increasing body of experimental data have suggested that aberrant functional interactions between large-scale networks may be the most plausible explanation of psychopathology across multiple mental disorders, including substance-related and addictive disorders. In the current research, we have i...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139645/ https://www.ncbi.nlm.nih.gov/pubmed/32121183 http://dx.doi.org/10.3390/brainsci10030136 |
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author | Imperatori, Claudio Massullo, Chiara Carbone, Giuseppe Alessio Panno, Angelo Giacchini, Marta Capriotti, Cristina Lucarini, Elisa Ramella Zampa, Benedetta Murillo-Rodríguez, Eric Machado, Sérgio Farina, Benedetto |
author_facet | Imperatori, Claudio Massullo, Chiara Carbone, Giuseppe Alessio Panno, Angelo Giacchini, Marta Capriotti, Cristina Lucarini, Elisa Ramella Zampa, Benedetta Murillo-Rodríguez, Eric Machado, Sérgio Farina, Benedetto |
author_sort | Imperatori, Claudio |
collection | PubMed |
description | An increasing body of experimental data have suggested that aberrant functional interactions between large-scale networks may be the most plausible explanation of psychopathology across multiple mental disorders, including substance-related and addictive disorders. In the current research, we have investigated the association between problematic cannabis use (PCU) and triple-network electroencephalographic (EEG) functional connectivity. Twelve participants with PCU and 24 non-PCU participants were included in the study. EEG recordings were performed during resting state (RS). The exact Low-Resolution Electromagnetic Tomography software (eLORETA) was used for all EEG analyses. Compared to non-PCU, PCU participants showed an increased delta connectivity between the salience network (SN) and central executive network (CEN), specifically, between the dorsal anterior cingulate cortex and right posterior parietal cortex. The strength of delta connectivity between the SN and CEN was positively and significantly correlated with higher problematic patterns of cannabis use after controlling for age, sex, educational level, tobacco use, problematic alcohol use, and general psychopathology (r(p) = 0.40, p = 0.030). Taken together, our results show that individuals with PCU could be characterized by a specific dysfunctional interaction between the SN and CEN during RS, which might reflect the neurophysiological underpinnings of attentional and emotional processes of cannabis-related thoughts, memories, and craving. |
format | Online Article Text |
id | pubmed-7139645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71396452020-04-10 Increased Resting State Triple Network Functional Connectivity in Undergraduate Problematic Cannabis Users: A Preliminary EEG Coherence Study Imperatori, Claudio Massullo, Chiara Carbone, Giuseppe Alessio Panno, Angelo Giacchini, Marta Capriotti, Cristina Lucarini, Elisa Ramella Zampa, Benedetta Murillo-Rodríguez, Eric Machado, Sérgio Farina, Benedetto Brain Sci Article An increasing body of experimental data have suggested that aberrant functional interactions between large-scale networks may be the most plausible explanation of psychopathology across multiple mental disorders, including substance-related and addictive disorders. In the current research, we have investigated the association between problematic cannabis use (PCU) and triple-network electroencephalographic (EEG) functional connectivity. Twelve participants with PCU and 24 non-PCU participants were included in the study. EEG recordings were performed during resting state (RS). The exact Low-Resolution Electromagnetic Tomography software (eLORETA) was used for all EEG analyses. Compared to non-PCU, PCU participants showed an increased delta connectivity between the salience network (SN) and central executive network (CEN), specifically, between the dorsal anterior cingulate cortex and right posterior parietal cortex. The strength of delta connectivity between the SN and CEN was positively and significantly correlated with higher problematic patterns of cannabis use after controlling for age, sex, educational level, tobacco use, problematic alcohol use, and general psychopathology (r(p) = 0.40, p = 0.030). Taken together, our results show that individuals with PCU could be characterized by a specific dysfunctional interaction between the SN and CEN during RS, which might reflect the neurophysiological underpinnings of attentional and emotional processes of cannabis-related thoughts, memories, and craving. MDPI 2020-02-28 /pmc/articles/PMC7139645/ /pubmed/32121183 http://dx.doi.org/10.3390/brainsci10030136 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Imperatori, Claudio Massullo, Chiara Carbone, Giuseppe Alessio Panno, Angelo Giacchini, Marta Capriotti, Cristina Lucarini, Elisa Ramella Zampa, Benedetta Murillo-Rodríguez, Eric Machado, Sérgio Farina, Benedetto Increased Resting State Triple Network Functional Connectivity in Undergraduate Problematic Cannabis Users: A Preliminary EEG Coherence Study |
title | Increased Resting State Triple Network Functional Connectivity in Undergraduate Problematic Cannabis Users: A Preliminary EEG Coherence Study |
title_full | Increased Resting State Triple Network Functional Connectivity in Undergraduate Problematic Cannabis Users: A Preliminary EEG Coherence Study |
title_fullStr | Increased Resting State Triple Network Functional Connectivity in Undergraduate Problematic Cannabis Users: A Preliminary EEG Coherence Study |
title_full_unstemmed | Increased Resting State Triple Network Functional Connectivity in Undergraduate Problematic Cannabis Users: A Preliminary EEG Coherence Study |
title_short | Increased Resting State Triple Network Functional Connectivity in Undergraduate Problematic Cannabis Users: A Preliminary EEG Coherence Study |
title_sort | increased resting state triple network functional connectivity in undergraduate problematic cannabis users: a preliminary eeg coherence study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139645/ https://www.ncbi.nlm.nih.gov/pubmed/32121183 http://dx.doi.org/10.3390/brainsci10030136 |
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