Antisense Oligonucleotide in LNA-Gapmer Design Targeting TGFBR2—A Key Single Gene Target for Safe and Effective Inhibition of TGFβ Signaling

Antisense Oligonucleotides (ASOs) are an emerging drug class in gene modification. In our study we developed a safe, stable, and effective ASO drug candidate in locked nucleic acid (LNA)-gapmer design, targeting TGFβ receptor II (TGFBR2) mRNA. Discovery was performed as a process using state-of-the-...

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Detalles Bibliográficos
Autores principales: Kuespert, Sabrina, Heydn, Rosmarie, Peters, Sebastian, Wirkert, Eva, Meyer, Anne-Louise, Siebörger, Mareile, Johannesen, Siw, Aigner, Ludwig, Bogdahn, Ulrich, Bruun, Tim-Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139664/
https://www.ncbi.nlm.nih.gov/pubmed/32178467
http://dx.doi.org/10.3390/ijms21061952

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