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The Effect of Cholecystectomy on the Risk of Colorectal Cancer in Patients with Gallbladder Stones
To evaluate the risk of colorectal cancer (CRC) after cholecystectomy for gallbladder stones (GBS). Methods: This nationwide population-based cohort study analyzed the inpatient data from the Taiwan National Health Insurance Research Database. The study cohort comprised of 83,963 patients aged ≥ 20...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139669/ https://www.ncbi.nlm.nih.gov/pubmed/32120781 http://dx.doi.org/10.3390/cancers12030550 |
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author | Chen, Chien-Hua Lin, Cheng-Li Kao, Chia-Hung |
author_facet | Chen, Chien-Hua Lin, Cheng-Li Kao, Chia-Hung |
author_sort | Chen, Chien-Hua |
collection | PubMed |
description | To evaluate the risk of colorectal cancer (CRC) after cholecystectomy for gallbladder stones (GBS). Methods: This nationwide population-based cohort study analyzed the inpatient data from the Taiwan National Health Insurance Research Database. The study cohort comprised of 83,963 patients aged ≥ 20 years undergoing cholecystectomy for GBS between 2000 and 2010. The control cohort comprised the GBS patients without cholecystectomy, who were propensity matched with the study cohort at a 1:1 ratio based on age, sex, comorbidities, and the index date for cholecystectomy. Results: The cumulative incidence of CRC within 6 months of follow-up was higher in the cholecystectomy cohort than that in the non-cholecystectomy cohort (aHR (adjusted hazard ratio) = 7.90, 95% confidence interval (CI) = 6.27–9.94; log-rank test, p < 0.001). The cumulative incidence of CRC after 6 months of follow-up was lower in the cholecystectomy cohort than that in the non-cholecystectomy cohort (aHR = 0.66, 95% CI = 0.60–0.73; log-rank test, p < 0.001), but the reduced risk of CRC for the cholecystectomy cohort was statistically significant only in rectal cancer after separately considering females (aHR = 0.64, 95% CI = 0.46–0.88) and males (aHR = 0.59, 95% CI = 0.44–0.79). Conclusions: The positive association between cholecystectomy and the CRC risk within the first 6 months after cholecystectomy might be due to a detection bias or pre-existing CRC. However, cholecystectomy is associated with a decreased risk of rectal cancer, rather than proximal or distal colon cancer, after more than 6 months of follow-up. |
format | Online Article Text |
id | pubmed-7139669 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71396692020-04-10 The Effect of Cholecystectomy on the Risk of Colorectal Cancer in Patients with Gallbladder Stones Chen, Chien-Hua Lin, Cheng-Li Kao, Chia-Hung Cancers (Basel) Article To evaluate the risk of colorectal cancer (CRC) after cholecystectomy for gallbladder stones (GBS). Methods: This nationwide population-based cohort study analyzed the inpatient data from the Taiwan National Health Insurance Research Database. The study cohort comprised of 83,963 patients aged ≥ 20 years undergoing cholecystectomy for GBS between 2000 and 2010. The control cohort comprised the GBS patients without cholecystectomy, who were propensity matched with the study cohort at a 1:1 ratio based on age, sex, comorbidities, and the index date for cholecystectomy. Results: The cumulative incidence of CRC within 6 months of follow-up was higher in the cholecystectomy cohort than that in the non-cholecystectomy cohort (aHR (adjusted hazard ratio) = 7.90, 95% confidence interval (CI) = 6.27–9.94; log-rank test, p < 0.001). The cumulative incidence of CRC after 6 months of follow-up was lower in the cholecystectomy cohort than that in the non-cholecystectomy cohort (aHR = 0.66, 95% CI = 0.60–0.73; log-rank test, p < 0.001), but the reduced risk of CRC for the cholecystectomy cohort was statistically significant only in rectal cancer after separately considering females (aHR = 0.64, 95% CI = 0.46–0.88) and males (aHR = 0.59, 95% CI = 0.44–0.79). Conclusions: The positive association between cholecystectomy and the CRC risk within the first 6 months after cholecystectomy might be due to a detection bias or pre-existing CRC. However, cholecystectomy is associated with a decreased risk of rectal cancer, rather than proximal or distal colon cancer, after more than 6 months of follow-up. MDPI 2020-02-27 /pmc/articles/PMC7139669/ /pubmed/32120781 http://dx.doi.org/10.3390/cancers12030550 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chen, Chien-Hua Lin, Cheng-Li Kao, Chia-Hung The Effect of Cholecystectomy on the Risk of Colorectal Cancer in Patients with Gallbladder Stones |
title | The Effect of Cholecystectomy on the Risk of Colorectal Cancer in Patients with Gallbladder Stones |
title_full | The Effect of Cholecystectomy on the Risk of Colorectal Cancer in Patients with Gallbladder Stones |
title_fullStr | The Effect of Cholecystectomy on the Risk of Colorectal Cancer in Patients with Gallbladder Stones |
title_full_unstemmed | The Effect of Cholecystectomy on the Risk of Colorectal Cancer in Patients with Gallbladder Stones |
title_short | The Effect of Cholecystectomy on the Risk of Colorectal Cancer in Patients with Gallbladder Stones |
title_sort | effect of cholecystectomy on the risk of colorectal cancer in patients with gallbladder stones |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139669/ https://www.ncbi.nlm.nih.gov/pubmed/32120781 http://dx.doi.org/10.3390/cancers12030550 |
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