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The Effect of Cholecystectomy on the Risk of Colorectal Cancer in Patients with Gallbladder Stones

To evaluate the risk of colorectal cancer (CRC) after cholecystectomy for gallbladder stones (GBS). Methods: This nationwide population-based cohort study analyzed the inpatient data from the Taiwan National Health Insurance Research Database. The study cohort comprised of 83,963 patients aged ≥ 20...

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Autores principales: Chen, Chien-Hua, Lin, Cheng-Li, Kao, Chia-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139669/
https://www.ncbi.nlm.nih.gov/pubmed/32120781
http://dx.doi.org/10.3390/cancers12030550
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author Chen, Chien-Hua
Lin, Cheng-Li
Kao, Chia-Hung
author_facet Chen, Chien-Hua
Lin, Cheng-Li
Kao, Chia-Hung
author_sort Chen, Chien-Hua
collection PubMed
description To evaluate the risk of colorectal cancer (CRC) after cholecystectomy for gallbladder stones (GBS). Methods: This nationwide population-based cohort study analyzed the inpatient data from the Taiwan National Health Insurance Research Database. The study cohort comprised of 83,963 patients aged ≥ 20 years undergoing cholecystectomy for GBS between 2000 and 2010. The control cohort comprised the GBS patients without cholecystectomy, who were propensity matched with the study cohort at a 1:1 ratio based on age, sex, comorbidities, and the index date for cholecystectomy. Results: The cumulative incidence of CRC within 6 months of follow-up was higher in the cholecystectomy cohort than that in the non-cholecystectomy cohort (aHR (adjusted hazard ratio) = 7.90, 95% confidence interval (CI) = 6.27–9.94; log-rank test, p < 0.001). The cumulative incidence of CRC after 6 months of follow-up was lower in the cholecystectomy cohort than that in the non-cholecystectomy cohort (aHR = 0.66, 95% CI = 0.60–0.73; log-rank test, p < 0.001), but the reduced risk of CRC for the cholecystectomy cohort was statistically significant only in rectal cancer after separately considering females (aHR = 0.64, 95% CI = 0.46–0.88) and males (aHR = 0.59, 95% CI = 0.44–0.79). Conclusions: The positive association between cholecystectomy and the CRC risk within the first 6 months after cholecystectomy might be due to a detection bias or pre-existing CRC. However, cholecystectomy is associated with a decreased risk of rectal cancer, rather than proximal or distal colon cancer, after more than 6 months of follow-up.
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spelling pubmed-71396692020-04-10 The Effect of Cholecystectomy on the Risk of Colorectal Cancer in Patients with Gallbladder Stones Chen, Chien-Hua Lin, Cheng-Li Kao, Chia-Hung Cancers (Basel) Article To evaluate the risk of colorectal cancer (CRC) after cholecystectomy for gallbladder stones (GBS). Methods: This nationwide population-based cohort study analyzed the inpatient data from the Taiwan National Health Insurance Research Database. The study cohort comprised of 83,963 patients aged ≥ 20 years undergoing cholecystectomy for GBS between 2000 and 2010. The control cohort comprised the GBS patients without cholecystectomy, who were propensity matched with the study cohort at a 1:1 ratio based on age, sex, comorbidities, and the index date for cholecystectomy. Results: The cumulative incidence of CRC within 6 months of follow-up was higher in the cholecystectomy cohort than that in the non-cholecystectomy cohort (aHR (adjusted hazard ratio) = 7.90, 95% confidence interval (CI) = 6.27–9.94; log-rank test, p < 0.001). The cumulative incidence of CRC after 6 months of follow-up was lower in the cholecystectomy cohort than that in the non-cholecystectomy cohort (aHR = 0.66, 95% CI = 0.60–0.73; log-rank test, p < 0.001), but the reduced risk of CRC for the cholecystectomy cohort was statistically significant only in rectal cancer after separately considering females (aHR = 0.64, 95% CI = 0.46–0.88) and males (aHR = 0.59, 95% CI = 0.44–0.79). Conclusions: The positive association between cholecystectomy and the CRC risk within the first 6 months after cholecystectomy might be due to a detection bias or pre-existing CRC. However, cholecystectomy is associated with a decreased risk of rectal cancer, rather than proximal or distal colon cancer, after more than 6 months of follow-up. MDPI 2020-02-27 /pmc/articles/PMC7139669/ /pubmed/32120781 http://dx.doi.org/10.3390/cancers12030550 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Chien-Hua
Lin, Cheng-Li
Kao, Chia-Hung
The Effect of Cholecystectomy on the Risk of Colorectal Cancer in Patients with Gallbladder Stones
title The Effect of Cholecystectomy on the Risk of Colorectal Cancer in Patients with Gallbladder Stones
title_full The Effect of Cholecystectomy on the Risk of Colorectal Cancer in Patients with Gallbladder Stones
title_fullStr The Effect of Cholecystectomy on the Risk of Colorectal Cancer in Patients with Gallbladder Stones
title_full_unstemmed The Effect of Cholecystectomy on the Risk of Colorectal Cancer in Patients with Gallbladder Stones
title_short The Effect of Cholecystectomy on the Risk of Colorectal Cancer in Patients with Gallbladder Stones
title_sort effect of cholecystectomy on the risk of colorectal cancer in patients with gallbladder stones
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139669/
https://www.ncbi.nlm.nih.gov/pubmed/32120781
http://dx.doi.org/10.3390/cancers12030550
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